8-Quinolinecarbaldehyde

Bezeichnung:8-Quinolinecarbaldehyde

CAS-Nr38707-70-9

Englisch Name:8-Quinolinecarbaldehyde

CBNumberCB4155188

SummenformelC10H7NO

Molgewicht157.17

MOL-Datei38707-70-9.mol

8-Quinolinecarbaldehyde physikalisch-chemischer Eigenschaften

Schmelzpunkt	95-96°C
Siedepunkt	314.3±15.0 °C(Predicted)
Dichte	1.223±0.06 g/cm3(Predicted)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
Aggregatzustand	powder to crystal
pka	3.45±0.17(Predicted)
Farbe	Light orange to Yellow to Green
Wasserlöslichkeit	Insoluble in water.
Sensitive	Air Sensitive
BRN	113039
InChI	InChI=1S/C10H7NO/c12-7-9-4-1-3-8-5-2-6-11-10(8)9/h1-7H
InChIKey	OVZQVGZERAFSPI-UHFFFAOYSA-N
SMILES	N1C2C(=CC=CC=2C=O)C=CC=1
CAS Datenbank	38707-70-9(CAS DataBase Reference)

Sicherheit

Kennzeichnung gefährlicher	Xi
R-Sätze:	36/37/38-36/38-43
S-Sätze:	26-37/39-36/37
HazardClass	IRRITANT
HS Code	29334900

Gefahreninformationscode (GHS)

8-Quinolinecarbaldehyde Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
R36/38:Reizt die Augen und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S37/39:Bei der Arbeit geeignete Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
Chemische Eigenschaften
Off-white solid
Verwenden
Quinoline-8-carboxaldehyde is an important raw material and intermediate used in organic synthesis, pharmaceuticals agrochemicals and dyestuff fields.
Synthese

16032-35-2

38707-70-9

General method: 8-quinoline methanol was dissolved in anhydrous DMSO (10 v/v), 1 equivalent of polymer bromide was added, and the reaction mixture was stirred at room temperature for the indicated time (see Table 1). Upon completion of the reaction, the mixture was filtered and the polymer bed was washed with DMSO. The DMSO layers were combined and the reaction was quenched with an ice-water mixture and subsequently extracted with ether. The ether layer was washed sequentially with water and brine, dried over anhydrous sodium sulfate and concentrated to give pure 8-quinolinecarboxaldehyde. All products were structurally confirmed by nuclear magnetic resonance (NMR) and mass spectrometry (MS).
Einzelnachweise
[1] Tetrahedron Letters, 2011, vol. 52, # 51, p. 6971 - 6973
[2] Bioorganic and Medicinal Chemistry Letters, 2012, vol. 22, # 10, p. 3480 - 3484
[3] Angewandte Chemie - International Edition, 2016, vol. 55, # 31, p. 9084 - 9087
[4] Angew. Chem., 2016, vol. 128, # 31, p. 9230 - 9233,4

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