2-Chlorpropyldimethylammoniumchlorid

Bezeichnung:2-Chlorpropyldimethylammoniumchlorid

CAS-Nr4584-49-0

Englisch Name:2-Dimethylaminoisopropyl chloride hydrochloride

CBNumberCB3235881

SummenformelC5H13Cl2N

Molgewicht158.07

MOL-Datei4584-49-0.mol

Synonyma

2-Chlorpropyldimethylammoniumchlorid

2-Chlorpropyldimethylammoniumchlorid physikalisch-chemischer Eigenschaften

Schmelzpunkt	187-190 °C(lit.)
storage temp.	Store below +30°C.
Löslichkeit	2000g/l
Aggregatzustand	Crystalline Powder
Farbe	White to light cream
PH	5-6 (500g/l, H2O, 20℃)
Wasserlöslichkeit	2000 g/L (20 º C)
Sensitive	Hygroscopic
BRN	3670215
InChI	InChI=1S/C5H12ClN.ClH/c1-5(6)4-7(2)3;/h5H,4H2,1-3H3;1H
InChIKey	OCWGRWAYARCRTQ-UHFFFAOYSA-N
SMILES	C(Cl)(C)CN(C)C.Cl
CAS Datenbank	4584-49-0(CAS DataBase Reference)
EPA chemische Informationen	2-Chloro-N,N-dimethyl-1-propanamine hydrochloride (4584-49-0)

Sicherheit

Kennzeichnung gefährlicher	Xn,Xi
R-Sätze:	22-36/37/38
S-Sätze:	26-36
RIDADR	2811
WGK Germany	3
RTECS-Nr.	TY1225000
TSCA	Yes
HazardClass	6.1(b)
PackingGroup	III
HS Code	29211980

Gefahreninformationscode (GHS)

2-Dimethylaminoisopropyl chloride hydrochloride Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R22:Gesundheitsschädlich beim Verschlucken.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Chemische Eigenschaften
Colourless to pale beige crystalline powder
Verwenden
2-Chloro-N,N-dimethylpropylamine hydrochloride (DMIC) is used as intermediate for the syntheses of pharmaceuticals (e.g. isothipendyl, methadone and promethazine)
Verwenden
Hydrochloride salt of 2-Dimethylaminoisopropyl Chloride, used in the synthesis of analogues of lipophilic chalcones, which act as antitubercular agents.
Allgemeine Beschreibung
Off-white chunky solid.
Air & Water Reaktionen
2-Dimethylaminoisopropyl chloride hydrochloride is hygroscopic. Soluble in water.
Reaktivität anzeigen
2-Dimethylaminoisopropyl chloride hydrochloride is incompatible with strong oxidizing agents. . Amines are chemical bases. They neutralize acids to form salts plus water. These acid-base reactions are exothermic. The amount of heat that is evolved per mole of amine in a neutralization is largely independent of the strength of the amine as a base. Amines may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides.
Brandgefahr
Flash point data for 2-Dimethylaminoisopropyl chloride hydrochloride are not available; however, 2-Dimethylaminoisopropyl chloride hydrochloride is probably combustible.
Synthese

Following the procedure of Schultz and Sprague, J. Am. Chem. Soc., 70, 48 (1948), a solution containing 3.77 g. of 1-dimethylamino-2-propanol and 10 ml. of chloroform was cooled with stirring to a temperature of about 0?? C. A solution of 5.72 g. of freshly distilled thionylchloride in 2 ml. of chloroform was added thereto. The reaction mixture was allowed to come to ambient temperature over a period of about 30 minutes and was then heated to refluxing temperature for an additional 30 minutes. The precipitated material redissolved on heating. 1-Dimethylamino-2-chloropropane hydrochloride began to crystallize from the boiling solvent. The reaction mixture was cooled, diluted with ether and filtered. The reaction product comprising 1-dimethylamino-2-chloropropane hydrochloride weighed about 5.5 g. (95 percent yield). Recrystallization yielded purified 1-dimethylamino-2-chloropropane hydrochloride melting at 192??-194?? C.

2-Dimethylaminoisopropyl chloride hydrochloride Upstream-Materialien And Downstream Produkte

2-Chlorpropyldimethylammoniumchlorid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

4584-49-0, 2-Dimethylaminoisopropyl chloride hydrochloride Verwandte Suche:

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