Gentamicin, Sulfat (Salz) Produkt Beschreibung

Gentamycin sulfate Struktur
1405-41-0
  • CAS-Nr.1405-41-0
  • Bezeichnung:Gentamicin, Sulfat (Salz)
  • Englisch Name:Gentamycin sulfate
  • Synonyma:Gentamicin, Sulfat (Salz)
    Gentak;100ppm;Pangram;sch9724;Gentalin;Genticyn;Septopal;Sulmycin;U-gencin;Urocydin
  • CBNumber:CB2733991
  • Summenformel:C60H127N15O26S
  • Molgewicht:1506.8
  • MOL-Datei:1405-41-0.mol
Gentamicin, Sulfat (Salz) physikalisch-chemischer Eigenschaften
  • Schmelzpunkt: :218-237°C
  • alpha  :D25 +102°
  • Dichte :1.000 g/cm3
  • storage temp.  :2-8°C
  • Löslichkeit :H2O: 50 mg/mL As stock solution, store at −20°C. Stable at 37°C for 5 days.
  • Aggregatzustand :powder
  • Farbe :colorless to light yellow
  • PH :4.0-5.5 (0.1g/mL in H2O)
  • Optische Aktivität :[α]20/D +110±8°, c = 1% in H2O
  • Wasserlöslichkeit :Soluble in water
  • Merck  :13,4403
  • InChIKey :RDEIXVOBVLKYNT-HDZPSJEVSA-N
  • CAS Datenbank :1405-41-0(CAS DataBase Reference)
  • EPA chemische Informationen :Gentamicin sulfate (1405-41-0)
Sicherheit
  • Kennzeichnung gefährlicher :Xn
  • R-Sätze: :42/43
  • S-Sätze: :23-36/37-45-22-24/25
  • WGK Germany  :2
  • RTECS-Nr. :LY2625000
  • F  :3
  • HS Code  :29419010
  • Toxizität :LD50 in mice (mg base/kg): 430 i.p.; 485 s.c.; 75 i.v.; >9050 orally (Black)

Gentamycin sulfate Chemische Eigenschaften,Einsatz,Produktion Methoden

  • R-Sätze Betriebsanweisung: R42/43:Sensibilisierung durch Einatmen und Hautkontakt möglich.
  • S-Sätze Betriebsanweisung: S23:Gas/Rauch/Dampf/Aerosol nicht einatmen(geeignete Bezeichnung(en) vom Hersteller anzugeben).
    S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
    S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
    S22:Staub nicht einatmen.
    S24/25:Berührung mit den Augen und der Haut vermeiden.
  • Chemische Eigenschaften White to buff-colored powder
  • Originator Garamycin,Schering,US,1966
  • Verwenden This compound is a complex mixture of the sulfates of gentamycin Cl, gentamycin CIA and gentamycin C2. Pharmaceutical incompatibilites include amphotericin, cephalosporins, erythromycin, heparin, penicillins, sodium bicarbonate, and sulfadiazine sodium. It is used as topical and systemic broad-spectrum antibiotic with bactericidal action; also used in ophthalmic drugs.
  • Verwenden Inhibits protein synthesis by binding to L6 protein of 50S ribosomal subunit. Antibacterial. Antibiotic complex consists of three closely related components, gentamicins C1, C2, C1a, and also gentamicin A which differs from the other members of the complex but is similar to Kanamycin C. Gentamicin C1: R1=R2=CH3 Gentamicin C2: R1=CH3; R2=H Gentamicin C1A: R1=R2=H
  • Verwenden Different viscosity grades available. Please inquire
  • Manufacturing Process Germination Stage: A lyophilized culture of M. purpurea is added to a 300 ml shake flask containing 100 ml of the following sterile medium: 3 grams bactobeef extract; 5 grams tryptose; 1 gram dextrose; 24 grams starch (soluble); 5 grams yeast extract; and 1,000 ml tap water. The flask and its contents are incubated for 5 days at 37°C on a rotary shaker (280 rpm, 2 inch stroke).
    Inoculum Preparation Stage: Two batches of inoculum of about 50 gallons each are prepared by the following method: A 25 ml inoculum (from the germination stage) is transferred to each of four 2-liter flasks, each containing 500 ml of the sterile medium utilized for germination. The flasks and contents are incubated for 5 days at 28°C on a rotary shaker (280 rpm, 2 inch stroke).
    The contents of the flasks are pooled, a 25 ml inoculum (taken from the pool) is added to each of twenty 2-liter flasks, each containing 500 ml of the following sterile medium: 30 grams soybean meal; 40 grams dextrose (cerelose); 1 gram calcium carbonate; 1,000 milliliters tap water. The flasks and their contents are incubated for 3 to 5 days at 28°C on a rotary shaker (280 rpm, 2 inch stroke). The broth is pooled and aseptically transferred into a sterile inoculum flask having a side arm (total volume, about 10 liters).
    The 10 liters of inoculum is aseptically transferred to a 65-gallon fermenter containing 50 gallons of the following sterile medium: 600 grams bacto-beef extract; 1,000 grams bacto-tryptose; 200 grams dextrose (cerelose); 4,800 grams starch (soluble); 1,000 grams yeast extract; 100 ml antifoamer GE 60 (General Electric Co. brand of silicone defoamer), or other defoamer; and tap water, qs to 50 gallons.
    The pH is adjusted to 6.9 to 7.0 before sterilization and aerobic fermentation is effected for 24 hours (until the packed cell volume is about 10 to 15%) under the following conditions: temperature, 37°C; sterile air input, 54 ft3/min; pressure, 7 psi; and agitation, 180 rpm.
    Fermentation Stage: One 50-gallon batch of inoculum is aseptically transferred to a 675-gallon fermenter (fermenter A) containing the following medium: 54.0 kg soybean meal; 72.0 kg cerelose; 9.0 kg calcium carbonate; 300 ml antifoamer GE 60; and 450 gallons soft water. The other 50-gallon batch of inoculum is aseptically transferred to a similar fermenter (fermenter B) containing the same medium as fermenter A with the addition of 200 mg of CoCl2 · 6H2O. Fermentation is effected in each fermenter at 35°C while agitating at 120 rpm with air input at 7 psi and 15 ft3/min. At various times, samples of the fermented broth are withdrawn and assayed for antibiotic production by the disc assay method. The following table shows the increase in yield effected by the presence of cobalt, (as described in US Patent 3,136,704).
    The conversion of the broth to gentamicin sulfate is described in US Patent 3,091,572.
  • Trademarks Apogen (King); Garamycin (Schering); Genoptic (Allergan); Gentacidin (Novartis); Gentafair (Pharmafair); Gentak (Akorn); U-Gencin (Pharmacia & Upjohn).
  • Therapeutic Function Antibacterial
  • Allgemeine Beschreibung Sulfate salt of an antibiotic complex produced by fermentation. Three closely related components that are chemically amino-saccharides. White to buff-colored powder. pH (4% solution) 3.5 to 5.5. Odorless.
  • Air & Water Reaktionen Water soluble. Hygroscopic.
  • Reaktivität anzeigen Gentamycin sulfate is very stable in solution, even in moderately acidic to strongly basic aqueous media.
  • Brandgefahr Flash point data for Gentamycin sulfate are not available; however, Gentamycin sulfate is probably combustible.
  • Sicherheitsprofil Poison by intravenous, intraperitoneal, and intramuscular routes. Moderately toxic by subcutaneous route. Human systemic effects: level changes for metals other than Na/K/Fe/Ca/P/Cl. An experimental teratogen. Other experimental reproductive effects. Mutation data reported. When heated to decomposition it emits very toxic fumes of SOx. See also other gentamycin entries.
Gentamycin sulfate Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Gentamicin, Sulfat (Salz) Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
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1405-41-0, Gentamycin sulfate Verwandte Suche:
  • GENTAMICIN 2,5-SULFATE HYDRATE
  • Alcomicin, Bristagen, Cidomycin, Duragentam, Garamycin, Garasol,Genoptic, Gentacidin, Gentacin,Gentaglyde, Gentalyn, Gentamicin C Complex Citrate, Gentibioptal, Genticin, Gentocin, Gentogram, Gent-Ophtal, Getalline, GM sulfate
  • 2-[4,6-Diamino-3-[3-amino-6-(1-methylaminoethyl)oxan-2-yl]oxy-2-hydroxy-cyclohexoxy]-5-methyl-4-methylamino-oxane-3,5-diol sulphate
  • Gentamycin sulfate
  • Gentamicin for peak identification
  • Gentamicin sulfate solution,1000ppm
  • Gentamicin sulfate solution,100ppm
  • Gentamicin Sulfate, 500X Solution
  • Gentamycin Sulfate/Micronomicin Sulfate
  • Gentamycin sulfate, Antibiotic for Culture Media Use Only
  • Gentamicin Sulfate Solution(10mg/ml)
  • Gentamicin Sulfate Solution(50mg/ml)
  • Gentamicin Sulfate, 100X Solution
  • genoptics.o.p.
  • gentalline
  • gentamicinsolution
  • nsc-82261
  • Gentak
  • Gentalin
  • Gentamycin, sulfate (salt) (8CI)
  • Genticyn
  • Gentrasul
  • Geramycin
  • Nichogencin
  • Ophtagram
  • Pangram
  • Refobacin
  • Refobacin 10
  • Refobacin L
  • Septopal
  • Sulmycin
  • U-gencin
  • Urocydin
  • Gentamycin Sulfate, Sterile-Filtered Aqueous Solution, Cell Culture Tested
  • C complex sulfate
  • Gentamicin Sulfate C1
  • GENTAMICIN SOLUTION 100MG/ML
  • GENTAMICIN SOLUTION 50MG/ML
  • Gentamicin A sulfate
  • GENTAMICIN SULFATE (WATER CONTENT 10%)
  • Antibacterial Gentamycin sulfate CAS 1405-41-0 white crystalline powder
  • Gentamicin sulfate, >=590 IU/mg
  • Gentamycin Sulfate - CAS 1405-41-0 - Calbiochem
  • GENTAMICIN SULPHATE STERILE
  • GentamycinSulphateBp98
  • Gentamicin C complex sulfate
  • GentamycinSulfate,Sterile-FilteredSolution,50mg/mlinDIWater
  • GentamycinSulfate,USPGrade
  • GentamycinSulfate,Sterile-FilteredSolution,10mg/mlinDIWater
  • GENTAMICINSULFATE,CRYSTALLINEPOWDER,USP
  • Dispagent
  • gentamicin solution 10mg/ml sterile*filtered
  • gentamicin solution cell culture tested
  • gentamicin standard solution
  • gentamicin sulfate cell culture tested
  • gentamicin sulfate from micromonospora purpurea
  • Gentamicin sulfate Micromonospora purpurea
  • gentamicin sulfate solution hybri-max*50mg/ml