Lynestrenol

Bezeichnung:Lynestrenol

CAS-Nr52-76-6

Englisch Name:Lynestrenol

CBNumberCB2441014

SummenformelC20H28O

Molgewicht284.44

MOL-Datei52-76-6.mol

Synonyma

Lynestrenol

Lynestrenol physikalisch-chemischer Eigenschaften

Schmelzpunkt	158°C
alpha	D -13° (chloroform)
Siedepunkt	366.92°C (rough estimate)
Dichte	1.0083 (rough estimate)
Brechungsindex	1.4500 (estimate)
storage temp.	2-8°C
Löslichkeit	Practically insoluble in water, soluble in acetone and in ethanol (96 per cent).
pka	13.12±0.40(Predicted)
Farbe	Crystals from MeOH
Merck	14,5629
CAS Datenbank	52-76-6
EPA chemische Informationen	Lynestrenol (52-76-6)

Sicherheit

RTECS-Nr.	RC8964300
HS Code	2937230000
Giftige Stoffe Daten	52-76-6(Hazardous Substances Data)

Gefahreninformationscode (GHS)

Lynestrenol Chemische Eigenschaften,Einsatz,Produktion Methoden

Chemische Eigenschaften
White or almost white, crystalline powder.
Verwenden
Progestogen;Antioestrogen
Verwenden
Lynestrenol is an orally available progestogen hormone used in contraception to avoid hereditary angiodema as well as in treatment of ischemic stroke.
Definition
ChEBI: Lynestrenol is a steroid. It derives from a hydride of an estrane.
Trademarks
Anacycline 101;Anacylin 101;Anacylin 28;Ancylin;Athilyn;Endometril;Exluton (a);Fysiognens;Fysionorm;Gestrol;Lindiol 2.5;Lyn_ratiopharm;Lyn_ratiophram_sequenz;Lyndeol;Lyndile tt;Lyndiol e.;Lyndiolett;Lynoenstrenol;Lyn-ratiopharm;Mini pregnon;Minifol;Minilyn;Neo lyndiol;Neo-lindiol;Neo-lynobol;Nonovulet;Noracyclin 22;Normophasic;Novostat;Org 485-50;Orgaluton;Orgametrol;Ovamezzo;Ovanone;Ovanon-e;Ovariostat;Ovoresta micro;Ovostat-28;Ovostat-micro;Phasicon;Physiostat;Physistat;Pregnon-28;Restovar.
Weltgesundheitsorganisation (WHO)
Lynestrenol, a synthetic progestogen, was introduced in the early 1960s as a component in oral contraceptive preparations. In 1967, as a result of new regulations required by the United States Food and Drug Administration, lynestrenol was submitted to long-term toxicity studies and by the early 1970s it was shown to be associated with an increased incidence of mammary tumours in beagle bitches which led to its withdrawal by at least one regulatory authority. Subsequently the validity of the beagle bitch model as a predictor of carcinogenicity of steroid contraceptives has been contested by many national regulatory authorities and lynestrenol remains available in some countries for contraceptive and other purposes. (Reference: (WHODI) WHO Drug Information, 1-3, 5-7, 1984)
Sicherheitsprofil
An experimental teratogen.Experimental reproductive effects. Human reproductiveeffects by ingestion and implant routes: menstrual cyclechanges or disorders, female fertility index, other fertilitychanges and effects on females. Questionable carcinoge

Lynestrenol Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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