Etynodioldi(acetat)

Bezeichnung:Etynodioldi(acetat)

CAS-Nr297-76-7

Englisch Name:Ethynodiol diacetate

CBNumberCB6749404

SummenformelC24H32O4

Molgewicht384.51

MOL-Datei297-76-7.mol

Synonyma

Etynodioldi(acetat)

Etynodioldi(acetat) physikalisch-chemischer Eigenschaften

Schmelzpunkt	~126-127°
alpha	D -72.5° (chloroform)
Siedepunkt	431.17°C (rough estimate)
Dichte	1.0474 (rough estimate)
Brechungsindex	1.4860 (estimate)
storage temp.	2-8°C
Löslichkeit	Chloroform (Slightly), DMSO (Slightly)
Aggregatzustand	Solid
Farbe	White
Wasserlöslichkeit	1.4mg/L(25 ºC)
CAS Datenbank	297-76-7(CAS DataBase Reference)
NIST chemische Informationen	Ethynodiol diacetate(297-76-7)
EPA chemische Informationen	Ethynodiol diacetate (297-76-7)

Sicherheit

Kennzeichnung gefährlicher	Xn
R-Sätze:	20/21/22-40
S-Sätze:	22-36
WGK Germany	3
RTECS-Nr.	RC8963000
HS Code	2937230000

Gefahreninformationscode (GHS)

Ethynodiol diacetate Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R20/21/22:Gesundheitsschädlich beim Einatmen,Verschlucken und Berührung mit der Haut.
R40:Verdacht auf krebserzeugende Wirkung.
S-Sätze Betriebsanweisung:
S22:Staub nicht einatmen.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Beschreibung
Ethynodiol diacetate is a synthetic progestogen. It prevents the development of osteoporosis in ovariectomized rats when administered at a dose of 9 μg/animal per day. Ethynodiol diacetate inhibits copulatory ovulation in rabbits. Formulations containing ethynodiol diacetate have been used as oral contraceptives.
Originator
Lutometrodiol,Searle,France,1965
Verwenden
Ethynodiol Diacetate is used as a hormonal contraceptive, birth control.
Verwenden
anticonvulsant
Definition
ChEBI: Ethynodiol diacetate is a steroid ester and a terminal acetylenic compound. It has a role as an estrogen receptor modulator, a contraceptive drug and a synthetic oral contraceptive. It is functionally related to an ethynodiol.
Manufacturing Process
A mixture of 30 parts of 17α-ethynyl-19-norandrost-4-ene-3β,17β-diol, 360 parts of dry pyridine, and 111 parts of acetic anhydride, under nitrogen, is stirred and heated at the reflux temperature for about 5 hours. This reaction mixture is cooled, then poured into approximately 3,500 parts of cold water and the resulting aqueous mixture is stirred at room temperature for about 0.5 hour. The precipitate which forms is collected by filtration, then is washed on the filter with water and dried in air. This solid material is extracted into ether, and the ether solution is washed successively with 10% aqueous
Therapeutic Function
Progestin; Oral contraceptive ingredient
Allgemeine Beschreibung
Ethynodiol diacetate, 19-norpregn-4-en-20-yne-3β,17α-diol diacetate, is a prodrug ofnorethindrone. A combination of hydrolysis of both estersand oxidation of the C3 alcohol to the ketone is necessary toprovide the fully active progestin.
Sicherheitsprofil
Suspected carcinogen. Human reproductive effects by ingestion: menstrual cycle changes. Experimental reproductive effects. Mutation data reported. A steroid. When heated to decomposition it emits acrid smoke and irritating fumes.

Ethynodiol diacetate Upstream-Materialien And Downstream Produkte

Etynodioldi(acetat) Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

297-76-7, Ethynodiol diacetate Verwandte Suche:

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