Norethisteronenantat

Gefahreninformationscode (GHS)

• Bildanzeige (GHS)

  

• Alarmwort

  Achtung

• Gefahrenhinweise

  H351：Kann vermutlich Krebs verursachen.

  H360：Kann die Fruchtbarkeit beeinträchtigen oder das Kind im Mutterleib schädigen.

  H362：Kann Säuglinge über die Muttermilch schädigen.

  H413：Kann für Wasserorganismen schädlich sein, mit langfristiger Wirkung.

• Sicherheit

  P201：Vor Gebrauch besondere Anweisungen einholen.

  P202：Vor Gebrauch alle Sicherheitshinweise lesen und verstehen.

  P260：Dampf/Aerosol/Nebel nicht einatmen.

  P263：Kontakt während der Schwangerschaft /und der Stillzeit vermeiden.

  P264：Nach Gebrauch gründlich waschen.

  P264：Nach Gebrauch gründlich waschen.

  P270：Bei Gebrauch nicht essen, trinken oder rauchen.

  P281：Vorgeschriebene persönliche Schutzausrüstung verwenden.

  P308+P313：BEI Exposition oder falls betroffen: Ärztlichen Rat einholen/ärztliche Hilfe hinzuziehen.

  P405：Unter Verschluss aufbewahren.

  P501：Inhalt/Behälter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen.

17alpha-Ethynyl-19-nortestosterone 17-heptanoate Chemische Eigenschaften,Einsatz,Produktion Methoden

• Originator

  Norigest,Schering

• Verwenden

  Norethisterone enanthate is a useful compound to study chem.-chem. interaction for predicting biological functions. It also has antigonadotropic effects and can be used as a hormonal contraceptive.

• Definition

  ChEBI: Norethindrone enanthate is a steroid ester.

• Manufacturing Process

  1 g 17-ethinyl-19-nor-testosteron was refluxed with 5 ml of enanthic acid anhydride on an oil bath at temperature 180°C 17 hours. Then the reaction mixture was distilled with water steam to the full disappearence of smell of enantic acid. After that it was washed with 2 N sodium hydroxide and finally with water to neutral, dried over sodium sulfate and evaporated to dryness. The oily residue was rubbed with some drops of methanol and stood at -8°C 24 hours to give the crystals of 3-endol diester; MP: 82°-84°C, 2 g of it was dissolved in 120 ml of methanol and heated with 1.2 ml concentrated hydrochloric acid. The partly saponified product was distilled with water steam to full disappearence of smell of enantic acid. The residue was mixed with ether, washed with 2 N sulfuric acid, 2 N sodium hydroxide, finally with water to neutral dried over sodium sulfate and evaporated to dryness. The residue was stirred with pentane and cooled for crystallization. Pure enanthate was crystallized after repeated solution in pentane. 17-α-Ethinyl-19nortestosterone enanthate had MP: 68°-71°C.

• Trademarks

  Binovum;Brevicon;Brevinor;Conceplan;Doryxas;Gesta plan;Lg 335;Menonorm;Miconor;Neocon;Nor 50;Norimin;Noristerat;Norlutate acetate;Nor-q-d;Norquentiel;Norquest fe;Novulon;Nur-isterate;Orlestrin;Ortho-novum;Ovcon-50;Ovismen;Ovysmen;Tri-norinyl.

• Therapeutic Function

  Progestin

• Weltgesundheitsorganisation (WHO)

  Norethisterone enantate was introduced in 1978 for use as a longacting injectable contraceptive. Risk-benefit judgements differ significantly from country to country, having regard to differing national circumstances. Norethisterone enantate is, however, widely available and is included as a complementary drug in the WHO Model List of Essential Drugs. (Reference: (WHODI) WHO Drug Information, 2(1), , 1988)

• Sicherheitsprofil

  An experimental teratogen.Questionable carcinogen with experimental tumorigenicdata. Human systemic effects by intravenous route:increased intraocular pressure. Human reproductiveeffects by intramuscular route: menstrual cycle changes ordisorders, ch

17alpha-Ethynyl-19-nortestosterone 17-heptanoate Upstream-Materialien And Downstream Produkte

Norethisteronenantat Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global(165)Suppliers

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