oestriol

Bezeichnung:oestriol

CAS-Nr50-27-1

Englisch Name:Estriol

CBNumberCB1687589

SummenformelC18H24O3

Molgewicht288.38

MOL-Datei50-27-1.mol

Synonyma

oestriol

oestriol physikalisch-chemischer Eigenschaften

Schmelzpunkt	280-282 °C(lit.)
alpha	D25 +58° ±5° (0.04 g in 1 ml dioxane)
Siedepunkt	370.61°C (rough estimate)
Dichte	1.27
Brechungsindex	58 ° (C=0.4, Dioxane)
Flammpunkt	9℃
storage temp.	2-8°C
Löslichkeit	Practically insoluble in water, sparingly soluble in ethanol (96 per cent).
Aggregatzustand	Solid
pka	pKa 10.38±0.02(H2O t=23±2 Iunspeci?ed) (Uncertain)
Farbe	White to Off-White
Optische Aktivität	+6127 (95% ethanol)
Wasserlöslichkeit	3.2mg/L(25 ºC)
Merck	3707
BRN	2508172
InChIKey	PROQIPRRNZUXQM-ZXXIGWHRSA-N
CAS Datenbank	50-27-1(CAS DataBase Reference)
NIST chemische Informationen	Estriol(50-27-1)
EPA chemische Informationen	Estriol (50-27-1)

Sicherheit

Kennzeichnung gefährlicher	T,F
R-Sätze:	60-61-40-45-39/23/24/25-23/24/25-11
S-Sätze:	53-22-36/37/39-45-36/37-16
RIDADR	UN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany	3
RTECS-Nr.	KG8225000
F	8-10
HS Code	29072990
Giftige Stoffe Daten	50-27-1(Hazardous Substances Data)
Toxizität	LD50 oral in rat: > 2gm/kg

Gefahreninformationscode (GHS)

Estriol Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R60:Kann die Fortpflanzungsfähigkeit beeinträchtigen.
R61:Kann das Kind im Mutterleib schädigen.
R40:Verdacht auf krebserzeugende Wirkung.
R45:Kann Krebs erzeugen.
S-Sätze Betriebsanweisung:
S53:Exposition vermeiden - vor Gebrauch besondere Anweisungen einholen.
S22:Staub nicht einatmen.
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
Beschreibung
Estriol is significantly less active than estradiol; however, it has a selective ability to stimulate blood flow and restoration of genital epithelium. In addition, using this drug reduces mental symptoms of menopausal syndrome. It is used in the premenopausal and menopausal periods, for skin atrophy and signs of genital degeneration, and so on.
Beschreibung
Estriol is a metabolite of estradiol and a major estrogen produced in the later stages of pregnancy. In a longitudinal study in healthy pregnant women, total plasma estriol levels increased from <10 ng/ml at 8-10 weeks gestation to approximately 150 ng/ml at week 38. The majority of the estriol synthesized in the later stages of pregnancy originates from fetal dehydroepiandrosterone sulfate (DHEAS) and serves as a direct marker of fetal adrenal gland activity. Saliva contains primarily unbound and unconjugated estriol and is commonly used for monitoring estriol levels. Plasma levels of estriol in males and non-pregnant females is less than 2 ng/ml.
Chemische Eigenschaften
White or almost white, crystalline powder.
Verwenden
A metabolite of Estradiol. An estrogenic metabolite considerably less potent than the hormone Estradiol
Verwenden
A metabolite of Estradiol (E888000). An estrogenic metabolite considerably less potent than the hormone Estradiol (E888000).
Verwenden
17b-estradiol metabolite, primary estrogen in urine
Definition
ChEBI: A 3-hydroxy steroid that is estra-1,3,5(10)-trien-3-ol substituted by additional hydroxy groups at positions 16 and 17 (16alpha,17beta-stereoisomer).
Trademarks
Theelol (Parke-Davis).
Allgemeine Beschreibung
Estriol, estra-1,3,5(10)-triene-3,16 ,17 -triol, is available for compounding into several differentformulations for use in HRT. It can be used alone or in combinationswith estradiol (Bi-Est) or with estradiol and estrone(Tri-Est).
Hazard
A carcinogen (OSHA).
Sicherheitsprofil
Suspected carcinogen with experimental carcinogenic, neoplastigenic, tumorigenic, and teratogenic data. Other experimental reproductive effects. Mutation data reported. A steroid drug for the treatment of menopause. When heated to decomposition it emits acrid smoke and irritating fumes.
Synthese
Estriol, estra-1,3,5(10)-trien-3,16|á,17|?-triol (28.1.25), is proposed to be synthesized from the methyl ester of estrone (28.1.8). Methyl ester of estrone is reacted with isopropenylacetate in the presence of p-toluenesulfonic acid, forming the corresponding enolacetate (28.1.23). The resulting enolacetate is oxidized to an epoxide using perbenzoic acid. The resulting epoxide (28.1.24) undergoes reduction by lithium aluminum hydride to.
läuterung methode
Crystallise estriol from EtOH/ethyl acetate. Also purify it by countercurrent distribution with cyclohexane/EtOAc (1:1) and EtOH/H2O (1:1). The UV (EtOH) has max at 280nm ( 2,090 M-1cm-1). [Huffmann & Lott 71 719 1949, Leeds et al. J Am Chem Soc 76 2943 1954, Beilstein 6 IV 7550.]

Estriol Upstream-Materialien And Downstream Produkte

oestriol Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

50-27-1, Estriol Verwandte Suche:

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