Olmesartan Struktur

Olmesartan

Bezeichnung:Olmesartan

Englisch Name:Olmesartan

CBNumberCB2350011

SummenformelC24H26N6O3

Molgewicht446.5

Olmesartan physikalisch-chemischer Eigenschaften

Schmelzpunkt	186-188°C
Siedepunkt	738.3±70.0 °C(Predicted)
Dichte	1.33
storage temp.	2-8°C
Löslichkeit	DMSO (Slightly), Methanol (Slightly, Heated)
pka	2.39±0.50(Predicted)
Aggregatzustand	powder
Farbe	white to beige
Stabilität	Hygroscopic
CAS Datenbank	144689-24-7(CAS DataBase Reference)

Sicherheit

Gefahreninformationscode (GHS)

Chemische Eigenschaften
White Solid
Verwenden
An labelled angiotensin II receptor antagonist. Used as an anti-hypertensive
Verwenden
An angiotensin II (AT1) receptor antagonist
Verwenden
Angiotensin II inhibitor, antihypertensive
Verwenden
Olmesartan Acid (Olmesartan EP Impurity A) is an angiotensin II receptor antagonist. Used as an anti-hypertensive.
Definition
ChEBI: Olmesartan is a biphenylyltetrazole. It has a role as an antihypertensive agent and an angiotensin receptor antagonist.
Allgemeine Beschreibung
Olmesartan medoxomil, (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl-5-(2-hydroxypropan-2-yl)-2-propyl-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]imidazole-4-carboxylate (Benicar, Olmetec) uses the tetrazolering system as its acidic system, which participates inreceptor binding.When administered to a patient, the drugis rapidly and completely bioactivated by ester hydrolysis ofthe medoxomil during absorption from the gastrointestinaltract. Once the prodrug is converted to the active form, virtuallyno further metabolism occurs. In September 2007, theFood and Drug Administration (FDA) approved its use as acombination product with the calcium channel blocker amlodipinefor the management of hypertension. This combinationproduct is sold under the tradename of Azor.
Biochem/physiol Actions
Olmesartan possesses anti-inflammatory and anti-oxidative stress properties. It protects neuronal cells against oligomerized amyloid β (Aβ)-induced cellular senescence.
Lager
Store at +4°C