Dextromethorphan hydrobromide monohydrate

Bezeichnung:Dextromethorphan hydrobromide monohydrate

Englisch Name:Dextromethorphan hydrobromide monohydrate

CBNumberCB6131946

SummenformelC18H28BrNO2

Molgewicht370.33

Dextromethorphan hydrobromide monohydrate physikalisch-chemischer Eigenschaften

Schmelzpunkt	116-119°C
alpha	[α]D25 +26～+30° (c=1.85, H2O)
Flammpunkt	11 °C
storage temp.	Store at RT
Löslichkeit	Sparingly soluble in water, freely soluble in ethanol (96 per cent).
Aggregatzustand	solid
Farbe	White to Off-White
PH	pH (10g/l, 25℃) : 5.2～6.5
BRN	6453793
InChIKey	QYPSYPPSHXDFLV-UHFFFAOYSA-N
LogP	1.351 (est)
CAS Datenbank	6700-34-1(CAS DataBase Reference)

Sicherheit

Kennzeichnung gefährlicher	F,T
R-Sätze:	11-23/24/25-39/23/24/25
S-Sätze:	7-16-36/37-45
WGK Germany	3
HS Code	3822000002

Gefahreninformationscode (GHS)

Beschreibung
Dextromethorphan (DXM) is a dextratrorotatory morphinan with structural similarity to levorphanol, codeine, and morphine. Because of its strong antitussive effects, dextromethorphan is widely used as a cough suppressant. However, it does not provoke opioid activity as is characteristic of several other morphine derivatives. DXM binds to and inhibits NMDA (IC₅₀ = 0.55 μM) and nicotinic receptors (IC₅₀s = 0.7-3.9 μM) and blocks receptor-gated and voltage-gated calcium channels (IC₅₀ = 60 μM) and voltage-gated sodium channels (IC₅₀ = 78 μM). DXM has been used in multimodal analgesic therapies for acute and neuropathic pain.
Chemische Eigenschaften
White Solid
Verwenden
An antitussive drug. Orally active synthetic morphine analog. Analgesic (narcotic). Racemethorphan and levomethorpham are controlled substances (opiates).
Verwenden
Antitussive;Opioid ligand
Definition
ChEBI: Dextromethorphan hydrobromide is the hydrobromide and monohydrate of the antitussive drug dextromethorphan. It is a hydrate and a hydrobromide. It contains a dextromethorphan.
Trademarks
Benylin DM (Parke-Davis); Dextromethorphan Hydrobromide OROS Tablets (Ciba-Geigy); Drixoral Cough (Schering-Plough HealthCare); PediaCare 1 (McNeil Consumer); Romilar (Hoffmann-LaRoche-International); St. Joseph Cough Syrup (Schering-Plough HealthCare).
Biologische Aktivität
Non-competitive, low affinity NMDA receptor antagonist. Antitussive, anticonvulsive and neuroprotective agent.