Mitiglinide calcium dihydrate

Bezeichnung:Mitiglinide calcium dihydrate

CAS-Nr207844-01-7

Englisch Name:Mitiglinide calcium dihydrate

CBNumberCB2336628

SummenformelC38H52CaN2O8

Molgewicht704.91

MOL-Datei207844-01-7.mol

Mitiglinide calcium dihydrate physikalisch-chemischer Eigenschaften

Schmelzpunkt	179-185°C
storage temp.	Inert atmosphere,Room Temperature
Löslichkeit	Methanol (Slightly)
Aggregatzustand	Solid
Farbe	White
InChIKey	QEVLNUAVAONTEW-HNIWBTCONA-L
SMILES	N1(C[C@]2([H])CCCC[C@]2([H])C1)C(=O)C[C@H](CC1=CC=CC=C1)C(=O)O[Ca]OC(=O)[C@@H](CC1=CC=CC=C1)CC(=O)N1C[C@@]2([H])CCCC[C@@]2([H])C1.O.O \|&1:2,8,14,29,42,48,r\|
CAS Datenbank	207844-01-7(CAS DataBase Reference)

Mitiglinide calcium dihydrate Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung
Mitiglinide calcium hydrate (KAD-1229) is an insulinotropic agent. Mitiglinide calcium hydrate is highly specific to the Kir6.2/SUR1 complex (the pancreatic beta-cell KATP channel). Mitiglinide is a drug for the treatment of type 2 diabetes. It may stimulate insulin secretion in beta-cells by closing off ATP dependant potassium ion channels.
Chemische Eigenschaften
White Solid
Verwenden
KAD-1229 Calcium Hydrate (Mitiglinide calcium dihydrate) could binds to sulfonylurea receptors and inhibits the activity of ATP-sensitive K+ channel in MIN 6 cells. Antidiabetic.
Mechanism of action
Mitiglinide is thought to stimulate insulin secretion by closing the ATP-sensitive K(+) (K(ATP)) channels in pancreatic beta-cells, and its early insulin release and short duration of action would be effective in improving postprandial hyperglycemia.
Synthese
The cis-six hydrogen isoindole of take are raw material, through react to obtain cis-N-chloracetyl six hydrogen isoindole with chloroacetyl chloride, then carry out alkylation reaction with N-hydrocinnamoyl camphor sultam, products therefrom obtains Mitiglinide calcium dihydrate through hydrolysis, salify. The synthesis route of Mitiglinide calcium dihydrate (S 21403).

[1]Yuan, Z. T&Wang, S.J. Preparation method for Mitiglinide calcium hydrate.2014[2026-01-07].
in vivo

Mitiglinide Calcium hydrate (1-3 mg/kg; p.o.) suppresses the increase in plasma glucose levels seen after a meal load and the area under the curve for plasma glucose levels (AUCglucose) up to 5 h after the meal load^[2].
Animal Model: Pregnant Wistar rats (12 weeks)^[2]
Dosage: 0.3 mg/kg, 1 mg/kg, 3 mg/kg
Administration: Oral administration
Result: Dose-dependently suppressed AUC_glucose levels.

Mitiglinide calcium dihydrate Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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Animal Model:	Pregnant Wistar rats (12 weeks)^[2]
Dosage:	0.3 mg/kg, 1 mg/kg, 3 mg/kg
Administration:	Oral administration
Result:	Dose-dependently suppressed AUC_glucose levels.