Tolazolinhydrochlorid

Bezeichnung:Tolazolinhydrochlorid

CAS-Nr59-97-2

Englisch Name:Tolazoline hydrochloride

CBNumberCB2277815

SummenformelC10H13ClN2

Molgewicht196.68

MOL-Datei59-97-2.mol

Synonyma

Tolazolinhydrochlorid

Tolazolinhydrochlorid physikalisch-chemischer Eigenschaften

Schmelzpunkt	172-176 °C
storage temp.	Inert atmosphere,Room Temperature
Löslichkeit	DMSO (Slightly, Heated), Methanol (Slightly)
Aggregatzustand	Crystalline Powder
Farbe	White to almost white
Sensitive	Hygroscopic
Merck	14,9506
Stabilität	Hygroscopic
CAS Datenbank	59-97-2(CAS DataBase Reference)
EPA chemische Informationen	Tolazoline hydrochloride (59-97-2)

Sicherheit

Kennzeichnung gefährlicher	Xn
R-Sätze:	22
S-Sätze:	22
RIDADR	2811
TSCA	Yes
HS Code	29332900
Toxizität	LD50 orl-rat: 1200 mg/kg NIIRDN 6,511,82

Gefahreninformationscode (GHS)

Tolazoline hydrochloride Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R22:Gesundheitsschädlich beim Verschlucken.
S-Sätze Betriebsanweisung:
S22:Staub nicht einatmen.
Chemische Eigenschaften
Pale Yellow Crystalline Solid
Originator
Priscoline,Ciba,US,1948
Verwenden
adrenergic blocker
Verwenden
Αn α-adrenergic antagonist. A peripheral vasodilator.
Verwenden
a-adrenergic antagonist. A peripheral vasodilator
Definition
ChEBI: Tolazoline hydrochloride is a member of benzenes.
Manufacturing Process
The phenyl-acetiminoether hydrochloride of the formula from 12 parts of benzylcyanide and ethanol and HCl is mixed with 8 parts of ethylenediamine hydrate which has been diluted with little alcohol, whereby the crystals go into solution. The whole is then heated on the water-bath until the ammonia odor has disappeared, cooled, concentrated caustic potash solution added, and the separated oil extracted with ether. The solution is dried with potassium carbonate and potassium hydroxide. After evaporation a pale oil is left which distills at 147°C under a pressure of 9 mm and which solidifies in the condenser to a white crystalline mass. The yield amounts to 90% of the theory. The hydrochloride melts at 168° to 170°C.
Trademarks
Tolazoline is INN and BAN.
Therapeutic Function
Vasodilator
Sicherheitsprofil
Poison by ingestion, intravenous, and intraperitoneal routes. Human systemic effects by intravenous route: change in heart rate, sweating, ulceration or bleeding from duodeum, ulceration or bleeding from small intestine, unspecified vascular effects. When heated to decomposition it emits very toxic fumes of NO, and HCl.
Veterinary Drugs and Treatments
flipping of lips); piloerection; clear lacrimal & nasal discharge; muscle fasciculations; apprehensiveness Uses/Indications Tolazoline is approved and indicated for the reversal of effects associated with xylazine in horses. It has also been used for this purpose in a variety of other species as well, but less safety and efficacy data is available.
In humans, the primary uses for tolazoline are: treatment of persistent pulmonary hypertension in newborns, adjunctive treatment and diagnosis

Tolazoline hydrochloride Upstream-Materialien And Downstream Produkte

Tolazolinhydrochlorid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

59-97-2, Tolazoline hydrochloride Verwandte Suche:

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