Phenylacetonitril

Gefahreninformationscode (GHS)

• Bildanzeige (GHS)

  

• Alarmwort

  Achtung

• Gefahrenhinweise

  H330：Lebensgefahr bei Einatmen.

• Sicherheit

  P260：Dampf/Aerosol/Nebel nicht einatmen.

  P264：Nach Gebrauch gründlich waschen.

  P264：Nach Gebrauch gründlich waschen.

  P270：Bei Gebrauch nicht essen, trinken oder rauchen.

  P280：Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.

Benzeneacetonitrile Chemische Eigenschaften,Einsatz,Produktion Methoden

• R-Sätze Betriebsanweisung:

  R22:Gesundheitsschädlich beim Verschlucken.
  R24:Giftig bei Berührung mit der Haut.
  R26:Sehr giftig beim Einatmen.
  R23/24/25:Giftig beim Einatmen, Verschlucken und Berührung mit der Haut.

• S-Sätze Betriebsanweisung:

  S28:Bei Berührung mit der Haut sofort abwaschen mit viel . . . (vom Hersteller anzugeben).
  S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
  S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
  S23:Gas/Rauch/Dampf/Aerosol nicht einatmen(geeignete Bezeichnung(en) vom Hersteller anzugeben).

• Aussehen Eigenschaften

  C8H7N; Phenylacetonitril, alpha-Tolunitril. Farblose bis gelbliche, ölige Flüssgkeit, übelriechend.

• Gefahren für Mensch und Umwelt

  Gesundheitsschädlich beim Verschlucken. Giftig bei Berührung mit der Haut. Sehr giftig beim Einatmen. Blausäurefreisetzung möglich. Blokade der Zellatmung, Atemnot und Blutdruckabfall möglich.
  Gefährliches Zersetzungsprodukt ist Cyanwasserstoff.
  LD₅₀ (oral, Ratte): 270 mg/kg. Gefahr der Hautresorption.

• Schutzmaßnahmen und Verhaltensregeln

  Schutzhandschuhe als kurzzeitiger Spritzschutz.

• Verhalten im Gefahrfall

  Dämpfe nicht einatmen.
  Mit flüssigkeitsbindendem Material z. B. Rench Rapid aufnehmen. Der Entsorgung zuführen. Nachreinigen.
  Kohlendioxid, Wasser, Schaum, Pulver.
  Brennbar. Mit Luft Bildung exposionsfähiger Gemische möglich. Im Brandfall kann Cyanwasserstoff entstehen.

• Erste Hilfe

  Nach Hautkontakt: Mit reichlich Wasser abwaschen.
  Nach Augenkontakt: Mit reichlich Wasser bei geöffnetem Lidspalt mindestens 10 Minuten ausspülen, Augenarzt hinzuziehen.
  Nach Einatmen: Frischluft, ggf. Atemspende. Sofort Arzt hinzuziehen.
  Nach Verschlucken: Mund ausspülen, Wasser trinken lassen, sofort Arzt hinzuziehen.
  Nach Kleidungskontakt: Kontaminierte Kleidung sofort entfernen.
  Ersthelfer: siehe gesonderten Anschlag

• Sachgerechte Entsorgung

  Getrennt als halogenfreie organische Lösemittelabfälle der Entsorgung zuführen.

• Beschreibung

  Benzyl cyanide is a colorless, oily liquid withan aromatic odor. Molecular weight=117.2; Boilingpoint=233.5℃; Freezing/Melting point=2 24; Vaporpressure=low , 0.40 at 20℃; Flash point=113℃(oc), also cited as 101℃. Hazard Identification (basedon NFPA-704 M Rating System): Health 3, Flammability 1,Reactivity 0. Insoluble in water.

• Chemische Eigenschaften

  colourless liquid

• Chemische Eigenschaften

  Benzyl cyanide is a colorless, oily liquid with an aromatic odor.

• Verwenden

  Phenylacetonitrile is used in organic synthesis for dyes, perfumes, pharmaceuticals, especially penicillin precursors. It is also used as a solvent.

• Verwenden

  Organic synthesis, especially penicillin precursors.

• Vorbereitung Methode

  Benzyl cyanide is synthesized by reaction of benzyl chloride with potassium cyanide or sodium cyanide . The nitrile is a natural constituent of plants and is a constituent of foods, particularly citrus fruits, papaya, cabbage, mushrooms, roasted onions, tomatoes, cocoa, tea, roasted peanuts and cauliflower .The benzyl cyanide, at least in part, is formed by breakdown of benzylglucosinolate in the plant material. Benzyl nitrile also is found in tap water, river water, sewage and in cigarette smoke ).

• Definition

  ChEBI: A nitrile that is acetonitrile where one of the methyl hydrogens is substituted by a phenyl group.

• Synthesis Reference(s)

  Canadian Journal of Chemistry, 39, p. 1340, 1961 DOI: 10.1139/v61-169
  Chemistry Letters, 13, p. 1511, 1984
  Organic Syntheses, Coll. Vol. 1, p. 107, 1941

• Allgemeine Beschreibung

  A colorless oily liquid with an aromatic odor. Insoluble in water and slightly denser than water. Contact may irritate skin, eyes, and mucous membranes. May be toxic by ingestion. Used to make other chemicals.

• Air & Water Reaktionen

  Benzeneacetonitrile is moisture sensitive. Insoluble in water.

• Reaktivität anzeigen

  PHENYLACETONITRILE can react with strong acids, strong bases, strong oxidizing agents and strong reducing agents. Benzeneacetonitrile may react vigorously with sodium hypochlorite. .

• Hazard

  Highly toxic, absorbed by skin.

• Health Hazard

  Benzyl cyanide is a highly toxic irritant that may be fatal if inhaled, swallowed or absorbed through the skin. The chemical causes eye, mucous membrane and skin irritation. Benzyl cyanide was applied as a 2% concentration in petroleum to the skin of 27 human volunteers and found to be nonsensitizing.

• Health Hazard

  Poisonous. May be fatal if inhaled, swallowed, or absorbed through skin. Contact may cause burns to skin and eyes.

• Brandgefahr

  When heated to decomposition, Benzeneacetonitrile emits very toxic fumes of cyanide and nitrogen oxides. Container may explode in heat of fire. Runoff from fire control water may give off poisonous gases. Avoid sodium hypochlorite.

• Industrielle Verwendung

  Benzyl cyanide is employed as a chemical intermediate for the synthesis of amphetamine, phenobarbital and methyl phenidylacetate. It is also used for perfumes and flavors and is, therefore, added to soaps, detergents, creams and lotions.

• Sicherheitsprofil

  Poison by ingestion, inhalation, skin contact, subcutaneous, and intraperitoneal routes. A skin irritant. Explosive reaction with sodium hypochlorite. Used in production of drugs of abuse. When heated to decomposition it emits very toxic fumes of CNand NOx. See also NITRILES

• mögliche Exposition

  (as CN): Benzyl cyanide is used in organic synthesis, especially of penicillin precursors. It is used as a chemical intermediate for amphetamines, phenobarbital; the stimulant, methyl phenidylacetate; esters as perfumes and flavors.

• Erste Hilfe

  If this chemical gets into the eyes, remove anycontact lenses at once and irrigate immediately for at least15 min, occasionally lifting upper and lower lids. Seek medical attention immediately. If this chemical contacts theskin, remove contaminated clothing and wash immediatelywith soap and water. Speed in removing material from skinis of extreme importance. Seek medical attention immediately. If this chemical has been inhaled, remove from exposure, begin rescue breathing (using universal precautions,including resuscitation mask) if breathing has stopped andCPR if heart action has stopped. Transfer promptly to amedical facility. When this chemical has been swallowed,get medical attention. Give large quantities of water andinduce vomiting. Do not make an unconscious personvomit. For cyanide poisoning, use amyl nitrate capsules ifsymptoms develop. All area employees should be trainedregularly in emergency measures for cyanide poisoning andin CPR. A cyanide antidote kit should be kept in the immediate work area and must be rapidly available. Kit ingredients should be replaced every 1
  2 years to ensurefreshness. Persons trained in the use of this kit, oxygen use,and CPR must be quickly available.

• Stoffwechsel

  Giacosa isolated phenylaceturic acid from the urine of a dog dosed with benzyl cyanide, while Adeline et al showed that in the dog, benzyl cyanide formed both benzoic acid and a small amount of ethereal sulfate. In rabbits, a large proportion of the cyano group could be accounted for as thiocyanate ion in the urine. There was a sex difference in the conversion with female rabbits excreting 70% of the dose as thiocyanate and males only 50%. However, cyanide was liberated slowly from i.p. or orally administered benzyl cyanide in rats and excreted in the urine as cyanide and thiocyanate, the proportion of the former increasing with the dose . Benzyl cyanide is oxidized by mouse liver microsomes to benzaldehyde and cyanide ion presumably via the intermediate mandelonitrile. The microsomal metabolism of benzyl cyanide and other nitriles was significantly increased when mice were pre treated with ethanol , suggesting that the ethanol-inducible cytochrome P-450 may play an important role in the metabolism of such compounds.

• Lager

  Color Code—Blue: Health Hazard: Store in asecure poison location. Store in tightly closed containers ina cool, well-ventilated area away from oxidizers and otherincompatible materials listed above. Sources of ignition,such as smoking and open flames, are prohibited where thischemical is used, handled, or stored in a manner that couldcreate a potential fire or explosion hazard.

• Versand/Shipping

  UN2470 Phenylacetonitrile, Hazard Class: 6.1; Labels: 6.1—Poisonous materials.

• läuterung methode

  Any benzyl isocyanide impurity can be removed by shaking vigorously with an equal volume of 50% H2SO4 at 60o, washing with saturated aqueous NaHCO3, then half-saturated NaCl solution, drying and fractionally distilling under reduced pressure. Distillation from CaH2 causes some decomposition of this compound: it is better to use P2O5. Other purification procedures include passage through a column of highly activated alumina, and distillation from Raney nickel. Precautions should be taken because of possible formation of free TOXIC cyanide, use an efficient fume cupboard.[Beilstein 9 IV 1663.]

• Inkompatibilitäten

  Violent reaction with strong oxidizers; sodium hypochlorite, lithium aluminum hydride. Nitriles may polymerize in the presence of metals and some metal compounds. They are incompatible with acids; mixing nitriles with strong oxidizing acids can lead to extremely violent reactions. Nitriles are generally incompatible with other oxidizing agents such as peroxides and epoxides. The combination of bases and nitriles can produce hydrogen cyanide. Nitriles are hydrolyzed in both aqueous acid and base to give carboxylic acids (or salts of carboxylic acids). These reactions generate heat. Peroxides convert nitriles to amides. Nitriles can react vigorously with reducing agents. Acetonitrile and propionitrile are soluble in water, but nitriles higher than propionitrile have low aqueous solubility. They are also insoluble in aqueous acids.

Benzeneacetonitrile Upstream-Materialien And Downstream Produkte

140-29-4, Benzeneacetonitrile Verwandte Suche: