Tolazolin

Bezeichnung:Tolazolin

CAS-Nr59-98-3

Englisch Name:Tolazoline

CBNumberCB0236054

SummenformelC10H12N2

Molgewicht160.22

MOL-Datei59-98-3.mol

Synonyma

Tolazolin

Tolazolin physikalisch-chemischer Eigenschaften

Schmelzpunkt	66-69 °C(lit.)
Siedepunkt	188°C/20mmHg(lit.)
Dichte	1.0849 (rough estimate)
Brechungsindex	1.6392 (estimate)
storage temp.	2-8°C
Löslichkeit	alcohol: freely soluble
pka	pKa 10.3(H2O t undefined I = 0.1) (Uncertain)
Aggregatzustand	Solid
Farbe	Crystals from pet ether
Merck	14,9506
CAS Datenbank	59-98-3(CAS DataBase Reference)
NIST chemische Informationen	1H-Imidazole, 4,5-dihydro-2-(phenylmethyl)-(59-98-3)
EPA chemische Informationen	1H-Imidazole, 4,5-dihydro-2-(phenylmethyl)- (59-98-3)

Sicherheit

Kennzeichnung gefährlicher	Xn
R-Sätze:	20/21/22-36/37/38
S-Sätze:	26-28-36/37/39-45
WGK Germany	3
RTECS-Nr.	NJ1925000
HS Code	2933299090
Toxizität	cyt-ham:lng 62,500 mg/L GMCRDC 27,95,81

Gefahreninformationscode (GHS)

Tolazoline Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R20/21/22:Gesundheitsschädlich beim Einatmen,Verschlucken und Berührung mit der Haut.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S28:Bei Berührung mit der Haut sofort abwaschen mit viel . . . (vom Hersteller anzugeben).
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
Originator
Priscoline,Ciba,US,1948
Verwenden
Tolazoline is used for treating stable forms of pulmonary hypertension in newborns, and in cases where systemic arterial oxygenation cannot be achieved in the usual manner under careful observation of professionals.
Verwenden
Reactant for synthesis of imidazoline-containing drug
Definition
ChEBI: A member of the class of imidazoles that is 4,5-dihydro-1H-imidazole substituted by a benzyl group.
Manufacturing Process
The phenyl-acetiminoether hydrochloride of the formula from 12 parts of benzylcyanide and ethanol and HCl is mixed with 8 parts of ethylenediamine hydrate which has been diluted with little alcohol, whereby the crystals go into solution. The whole is then heated on the water-bath until the ammonia odor has disappeared, cooled, concentrated caustic potash solution added, and the separated oil extracted with ether. The solution is dried with potassium carbonate and potassium hydroxide. After evaporation a pale oil is left which distills at 147°C under a pressure of 9 mm and which solidifies in the condenser to a white crystalline mass. The yield amounts to 90% of the theory. The hydrochloride melts at 168° to 170°C.
Therapeutic Function
Vasodilator
Allgemeine Beschreibung
2-Benzylimidazoline is an active vasodilator.
Pharmakologie
Tolazoline is a weak, reversible α-adrenoblocker that lowers resistance of peripheral blood vessels and elevates venous capacity. However, it also exhibits β-adrenomimetic activity, which consists of the stimulation of cardiac work and is manifest as tachycardia, cholinergic activity, which consists of stimulation of the gastrointestinal tract, and histamine-like activity, which consists of stimulation of gastric secretion.
Sicherheitsprofil
Poison by ingestion,intraperitoneal, and intravenous routes. Mutation data reported. When heated to decomposition it emits toxicfumes of NOx.
Synthese
Tolazoline, 2-benzyl-2-imidazoline (12.2.7), is synthesized by the heterocyclation of the ethyl ester of iminophenzylacetic acid with ethylendiamine (12.2.6), which forms the desired product (12.2.7) [32¨C35]. The structure of tolazoline is strikingly similar to |á-adrenergic agonists, which are antiedema sympathomimetics.

Tolazoline Upstream-Materialien And Downstream Produkte

Tolazolin Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

59-98-3, Tolazoline Verwandte Suche:

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