Tetryzolin

Bezeichnung:Tetryzolin

CAS-Nr84-22-0

Englisch Name:Tetryzoline

CBNumberCB5733093

SummenformelC13H16N2

Molgewicht200.28

MOL-Datei84-22-0.mol

Synonyma

Tetryzolin

Tetryzolin physikalisch-chemischer Eigenschaften

Schmelzpunkt	117-119 °C(Solv: heptane (142-82-5); ethanol (64-17-5))
Siedepunkt	393.5±21.0 °C(Predicted)
Dichte	1.20±0.1 g/cm3(Predicted)
Löslichkeit	Chloroform (Slightly), DMSO (Slightly)
Aggregatzustand	Solid
pka	pKa 10.51 (Uncertain)
Farbe	Off-White to Pale Yellow
NIST chemische Informationen	1H-Imidazole, 4,5-dihydro-2-(1,2,3,4-tetrahydro-1-naphthalenyl)-(84-22-0)

Sicherheit

Giftige Stoffe Daten

84-22-0(Hazardous Substances Data)

Gefahreninformationscode (GHS)

Tetryzoline Chemische Eigenschaften,Einsatz,Produktion Methoden

Originator
Tyzine,Pfizer,US,1954
Verwenden
Tetrahydrozoline is generally used in the form of eye drops for constriction of blood vessels as well as locally for minor inflammations and bites.
Definition
ChEBI: Tetryzoline is a member of imidazolines and a carboxamidine. It has a role as a sympathomimetic agent and a nasal decongestant. It is a conjugate base of a tetryzoline(1+).
Manufacturing Process
A mixture of 540 grams (9.0 mols) of ethylenediamine, 270 grams (1.53 mols) of 1,2,3,4tetrahydro-α-naphthoic acid, and 360 ml (4.32 mols) of concentrated hydrochloric acid was introduced into a two-liter, three-necked flask fitted with a thermometer, stirrer, and distillation takeoff. The mixture was distilled under a pressure of about 20 mm of mercury absolute until the temperature rose to 210°C. Thereafter, heating was continued under atmospheric pressure and when the temperature reached about 260°C, an exothermic reaction was initiated. The heat was then adjusted to maintain a reaction temperature of 275° to 280°C for 45 minutes and the mixture thereafter cooled to room temperature.
900 ml of 4 N hydrochloric acid was added and the aqueous layer stirred with warming until a clear, brown solution resulted. This brown solution was made strongly alkaline with sodium hydroxide. The oil that separated solidified and was collected on a filter leaving filtrate A. The solid was dissolved in 370 ml of alcohol with warming, and the solution was treated with 130 ml of concentrated hydrochloric acid with stirring and cooling. This acidified mixture was diluted with 300 ml of ether and chilled. The solid salt was collected and dried and the filtrate concentrated to approximately 300 ml, diluted with 300 ml of ether and the salt which separated collected and dried.
Filtrate A was extracted with ether, dried, acidified with alcoholic hydrogen chloride, and the salt which separated was collected and dried. There was thus obtained, when all the salt had been combined, 250 grams (69.3% of the theoretical yield) of 2-(1,2,3,4-tetrahydro-1-naphthyl)imidazoline hydrochloride, melting at 256° to 257°C.
Therapeutic Function
Nasal decongestant, Pharmaceutic aid
Synthese
Tetrahydrozoline, 2-(1,2,3,4-tetrahydro-1-naphthalenyl)-2-imidazoline (11.1.41), is synthesized in one step by the heterocyclization of 1-cyanotetraline with ethylenediamine [45].

Tetryzoline Upstream-Materialien And Downstream Produkte

Tetryzolin Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

84-22-0, Tetryzoline Verwandte Suche:

Send Inquriy