2-Methoxy-4-nitroanilin

Bezeichnung:2-Methoxy-4-nitroanilin

CAS-Nr97-52-9

Englisch Name:2-Methoxy-4-nitroaniline

CBNumberCB1693973

SummenformelC7H8N2O3

Molgewicht168.15

MOL-Datei97-52-9.mol

Synonyma

4-Nitro-o-anisidin

2-Methoxy-4-nitroanilin

2-Methoxy-4-nitroanilin physikalisch-chemischer Eigenschaften

Schmelzpunkt	140-142 °C(lit.)
Siedepunkt	337.07°C (rough estimate)
Dichte	1,211 g/cm³
Brechungsindex	1.6010 (estimate)
storage temp.	Store below +30°C.
Löslichkeit	0.2g/l
pka	1.02±0.10(Predicted)
Aggregatzustand	Crystalline Powder
Farbe	Yellow to orange
PH	6.2 (0.2g/l, H2O, 20℃)
Wasserlöslichkeit	slightly soluble
BRN	879619
InChIKey	GVBHRNIWBGTNQA-UHFFFAOYSA-N
CAS Datenbank	97-52-9(CAS DataBase Reference)
NIST chemische Informationen	Benzenamine, 2-methoxy-4-nitro-(97-52-9)
EPA chemische Informationen	2-Methoxy-4-nitroaniline (97-52-9)

Sicherheit

Kennzeichnung gefährlicher	Xn,Xi
R-Sätze:	22-36/37/38-20/21/22
S-Sätze:	26-37/39-36/37
RIDADR	UN 3077 9 / PGIII
WGK Germany	2
RTECS-Nr.	BZ7170000
Hazard Note	Irritant
TSCA	Yes
HS Code	29222900

Gefahreninformationscode (GHS)

2-Methoxy-4-nitroaniline Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R22:Gesundheitsschädlich beim Verschlucken.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
R20/21/22:Gesundheitsschädlich beim Einatmen,Verschlucken und Berührung mit der Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S37/39:Bei der Arbeit geeignete Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
Chemische Eigenschaften
2-Methoxy-4-nitroaniline is a yellow to orange crystalline powder. 2-Methoxy-4-nitroaniline (MONA) is a potential nonlinear optical (NLO) material, the N12–O19 bond length of MONA molecule is essentially controlled by the p-character of these hybrid orbitals and also by the nature of the N12–O19 bond. The molecular geometry of the compound is almost planar with the substituents[1].
Verwenden
2-Methoxy-4-nitroaniline is an important intermediate for preparing organic pigments and color bases of ice dyeing dyestuff. As a benzene dye intermediate, It is generally employed to prepare not only fast pigments but also as a printing and dyeing developer for cotton fabrics. In particular, 2-methoxy-4-nitroaniline is also important in production of some antineoplastic drugs[2-3].
Verwenden
2-Methoxy-4-nitroaniline is used as a photometric reagent for the determination of ethinylestradiol (ETE), a semi-synthetic estrogen that is widely used in oral contraceptives.
Allgemeine Beschreibung
2-Methoxy-4-nitroaniline is an important inducer of CYP1A2 owing to its small molecular size.
Flammability and Explosibility
Non flammable
Biochem/physiol Actions
The metabolism of 2-methoxy-4-nitroaniline (MNA) occurs via the hydroxylation of the phenyl ring to form 6-hydroxy MNA in Harlan Sprague Dawley rats and B6C3F(1)/N mice.
Solubility in organics
The change trend of the solubility magnitude in different monosolvents from high to low was as follows: N-methylpyrrolidone (NMP) > dimethyl sulfoxide (DMSO) > 1,4-dioxane > ethyl acetate > acetonitrile > ethanol > methanol > n-propanol > isopropanol > ethylene glycol (EG) > n-butanol > water[2].
Einzelnachweise
[1] Bao Y, et al. 2-Methoxy-4-nitroaniline Solubility in Several Monosolvents: Measurement, Correlation, and Solvent Effect Analysis. Journal of Chemical & Engineering Data, 2020; 65: 757–765.
[2] Degawa M, et al.2-Methoxy-4-nitroaniline is a selective inducer of cytochrome P450IA2 (CYP1A2) in rat liver. Cancer Letters, 1995; 96: 95-98.
[3] Ravikumar C, et al. Electronic absorption and vibrational spectra and nonlinear optical properties of 4-methoxy-2-nitroaniline. Physical Chemistry Chemical Physics, 2010; 12: 9452-9460.

2-Methoxy-4-nitroaniline Upstream-Materialien And Downstream Produkte

2-Methoxy-4-nitroanilin Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

97-52-9, 2-Methoxy-4-nitroaniline Verwandte Suche:

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