3-Brombenzylalkohol

Bezeichnung:3-Brombenzylalkohol

CAS-Nr15852-73-0

Englisch Name:3-Bromobenzyl alcohol

CBNumberCB1466508

SummenformelC7H7BrO

Molgewicht187.03

MOL-Datei15852-73-0.mol

Synonyma

3-Brombenzylalkohol

3-Brombenzylalkohol physikalisch-chemischer Eigenschaften

Schmelzpunkt	110-112
Siedepunkt	165 °C16 mm Hg(lit.)
Dichte	1.56 g/mL at 25 °C(lit.)
Brechungsindex	n20/D 1.584(lit.)
Flammpunkt	>230 °F
storage temp.	Sealed in dry,Room Temperature
Wasserlöslichkeit	Slightly soluble in water
pka	14.28±0.10(Predicted)
Aggregatzustand	clear liquid
Farbe	Colorless to Light yellow to Light orange
Wichte	1.560
BRN	2242512
InChI	InChI=1S/C7H7BrO/c8-7-3-1-2-6(4-7)5-9/h1-4,9H,5H2
InChIKey	FSWNRRSWFBXQCL-UHFFFAOYSA-N
SMILES	C1(CO)=CC=CC(Br)=C1
CAS Datenbank	15852-73-0(CAS DataBase Reference)
NIST chemische Informationen	3-Bromobenzyl alcohol(15852-73-0)

Sicherheit

Kennzeichnung gefährlicher	Xi
S-Sätze:	24/25
WGK Germany	3
Hazard Note	Irritant
HS Code	29062900
Speicherklasse	10 - Combustible liquids

Gefahreninformationscode (GHS)

3-Bromobenzyl alcohol Chemische Eigenschaften,Einsatz,Produktion Methoden

S-Sätze Betriebsanweisung:
S24/25:Berührung mit den Augen und der Haut vermeiden.
Chemische Eigenschaften
CLEAR COLOURLESS TO LIGHT YELLOW LIQUID
Verwenden
3-Bromobenzyl alcohol was employed in the preparation of tert-butyl 3-(3-bromophenyl)-2-cyanopropanoate and silyl ether.
Synthesis Reference(s)
Synthetic Communications, 19, p. 1217, 1989 DOI: 10.1080/00397918908054526
Synthese

3132-99-8

15852-73-0

Example 49: Synthesis of (3-bromophenyl)methanol Sodium borohydride (7.1 g, 186.1 mmol) was added in one batch to a solution of 3-bromobenzaldehyde (114.8 g, 620.4 mmol) in ethanol (650 mL) at 25 °C. The reaction mixture was stirred at room temperature for 1 hour. Upon completion of the reaction, the reaction was quenched with water (200 mL). After ethanol was removed by distillation under reduced pressure, the residue was dissolved in ethyl acetate (500 mL) and filtered. The filtrate was washed sequentially with water (150 mL) and brine (150 mL) and then dried over anhydrous sodium sulfate. After concentration under reduced pressure to remove the solvent, 115.8 g of 3-bromobenzyl alcohol was obtained in 99.8% yield.
Einzelnachweise
[1] Patent: US2009/203657, 2009, A1. Location in patent: Page/Page column 54
[2] Patent: US2009/203677, 2009, A1. Location in patent: Page/Page column 57; 58
[3] Patent: US2009/197871, 2009, A1. Location in patent: Page/Page column 57
[4] Patent: WO2009/100169, 2009, A1. Location in patent: Page/Page column 138
[5] European Journal of Medicinal Chemistry, 2016, vol. 108, p. 564 - 576

3-Bromobenzyl alcohol Upstream-Materialien And Downstream Produkte

3-Brombenzylalkohol Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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