gamma-(4-Bromphenyl)-N,N-dimethyl-2-pyridin-propanamin, (Z)-2-butendioat (1:1)

Bezeichnung:gamma-(4-Bromphenyl)-N,N-dimethyl-2-pyridin-propanamin, (Z)-2-butendioat (1:1)

CAS-Nr980-71-2

Englisch Name:Brompheniramine hydrogen maleate

CBNumberCB2736194

SummenformelC20H23BrN2O4

Molgewicht435.31

MOL-Datei980-71-2.mol

Synonyma

Brompheniraminhydrogenmaleat

gamma-(4-Bromphenyl)-N,N-dimethyl-2-pyridin-propanamin, (Z)-2-butendioat (1:1)

gamma-(4-Bromphenyl)-N,N-dimethyl-2-pyridin-propanamin, (Z)-2-butendioat (1:1) physikalisch-chemischer Eigenschaften

Schmelzpunkt	134-135°C
Flammpunkt	9℃
storage temp.	Inert atmosphere,Room Temperature
Löslichkeit	Soluble in water, freely soluble in ethanol (96 per cent), in methanol and in methylene chloride.
Aggregatzustand	Solid
Farbe	White to Off-White
maximale Wellenlänge (λmax)	261nm(lit.)
Merck	14,1443
Stabilität	Hygroscopic
InChIKey	SRGKFVAASLQVBO-BTJKTKAUSA-N
LogP	3.565 (est)
CAS Datenbank	980-71-2(CAS DataBase Reference)
EPA chemische Informationen	2-Pyridinepropanamine, .gamma.-(4-bromophenyl)-N,N-dimethyl-, (2Z)-2-butenedioate (1:1) (980-71-2)

Sicherheit

Kennzeichnung gefährlicher	Xn,Xi,T,F
R-Sätze:	22-39/23/24/25-23/24/25-11
S-Sätze:	36-45-36/37-16-7
RIDADR	3249
WGK Germany	3
RTECS-Nr.	US4025000
TSCA	Yes
HazardClass	6.1(b)
PackingGroup	III
HS Code	38220090

Gefahreninformationscode (GHS)

Brompheniramine hydrogen maleate Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R22:Gesundheitsschädlich beim Verschlucken.
S-Sätze Betriebsanweisung:
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Beschreibung
Brompheniramine is a first generation antihistamine of the propylamine class. It antagonizes histamine H₁ receptors (K_i = 6.06 nM) and also inhibits the reuptake of serotonin and norepinephrine.
Chemische Eigenschaften
White Solid
Originator
Dimetane,Robins,US,1957
Verwenden
An antihistamine and also an inhibitor of serotonin reuptake
Verwenden
This drug is only available in combination with other medications: Bromfed, Dimetane, Dimetapp, Drixomed, Histatab, Nasahist. The only difference between this agent and chlorpheniramine is the substitution of a bromine for a chlorine atom in brompheniramine.
Verwenden
Antihistaminic;H1 Antagonist
Definition
ChEBI: The maleic acid salt of brompheniramine. A histamine H1 receptor antagonist, it is used for the symptomatic relief of allergic conditions, including rhinitis and conjunctivitis.
Manufacturing Process
Initially, 4-bromobenzyl-cyanide is reacted with sodium amide and 2- chloropyridine to give bromophenyl-pyridyl acetonitrile. This is then reacted with sodium amide then dimethyl amino ethyl chloride to give 4-bromophenyldimethylaminoethyl- pyridyl acetonitrile. This intermediate is then hydrolyzed and decarboxylated to bromphenirame using 80% H2SO4 at 140°-150°C for 24 hours. The brompheniramine maleate may be made by reaction with maleic acid in ethanol followed by recrystallization from pentanol.
Trademarks
Dimetane (Wyeth).
Therapeutic Function
Antihistaminic
Allgemeine Beschreibung
Brompheniraminemaleate, (+)2-[p-bromo-α-[2-(dimethylamino)ethyl]benzyl]pyridine bimaleate (Dimetane), differs fromchlorpheniramine by the substitution of a bromine atom forthe chlorine atom. Its actions and uses are like those of chlorpheniramine.It has a half-life of 25 hours, which is almosttwice that of chlorpheniramine.
Nebenwirkungen
The side effects of this medication are similar to other classes of sedative antihistamines. Some medications include parabens. Patients sensitive to parabens may develop a sensitivity reaction.

Brompheniramine hydrogen maleate Upstream-Materialien And Downstream Produkte

gamma-(4-Bromphenyl)-N,N-dimethyl-2-pyridin-propanamin, (Z)-2-butendioat (1:1) Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

980-71-2, Brompheniramine hydrogen maleate Verwandte Suche:

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