3'-Nitroacetophenon

Bezeichnung:3'-Nitroacetophenon

CAS-Nr121-89-1

Englisch Name:3-Nitroacetophenone

CBNumberCB4400448

SummenformelC8H7NO3

Molgewicht165.15

MOL-Datei121-89-1.mol

Synonyma

3'-Nitroacetophenon

3'-Nitroacetophenon physikalisch-chemischer Eigenschaften

Schmelzpunkt	76-78 °C(lit.)
Siedepunkt	202 °C(lit.)
Dichte	1.3450 (rough estimate)
Dampfdruck	0.32Pa at 25℃
Brechungsindex	1.5468 (estimate)
Flammpunkt	202°C
storage temp.	Sealed in dry,Room Temperature
Löslichkeit	DMSO (Slightly), Methanol (Slightly)
Aggregatzustand	Crystalline Powder
Farbe	Yellow to yellow-green
Geruch (Odor)	Odorless
Wasserlöslichkeit	<0.01 g/100 mL at 20 ºC
BRN	743002
Stabilität	Stable. Incompatible with strong oxidizing agents, strong bases.
InChIKey	ARKIFHPFTHVKDT-UHFFFAOYSA-N
LogP	1.42
NIST chemische Informationen	3-Nitroacetophenone(121-89-1)
EPA chemische Informationen	3-Nitroacetophenone (121-89-1)

Sicherheit

Kennzeichnung gefährlicher	Xn
R-Sätze:	21
S-Sätze:	22-24/25
WGK Germany	2
RTECS-Nr.	AM9625000
TSCA	Yes
HS Code	29147090
Giftige Stoffe Daten	121-89-1(Hazardous Substances Data)
Toxizität	mouse,LD50,intraperitoneal,200mg/kg (200mg/kg),National Technical Information Service. Vol. AD277-689,

Gefahreninformationscode (GHS)

3-Nitroacetophenone Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R21:Gesundheitsschädlich bei Berührung mit der Haut.
S-Sätze Betriebsanweisung:
S22:Staub nicht einatmen.
S24/25:Berührung mit den Augen und der Haut vermeiden.
Chemische Eigenschaften
white to light beige crystalline powder or yellow needle-like crystals. soluble in hot water and ether, slightly soluble in ethanol. can be volatile with water vapor.
Verwenden
3''-Nitroacetophenone is used as a reactant in the synthesis of fluorine based aminothiazoles with antimicrobial activity.
Verwenden
3′-Nitroacetophenone can undergo high hydrostatic pressure-assisted reduction with Ni–Al alloy in water to form 1-(3-aminophenyl)ethanol.
Vorbereitung Methode
Acetophenone is carefully dissolved in concentrated sulfuric acid at 0 ℃, and mixed acid is added slowly below 0 ℃. The crude product is precipitated by quenching into ice, filtered, and washed acid free. Purification, mainly from the ortho isomer, is achieved by recrystallization from ethanol with significant lowering of the overall yield to ca. 55 %.
synthetische
3-Nitroacetophenone is synthesized from acetophenone by nitration.
Synthesis of 3-nitroacetophenone
Allgemeine Beschreibung
3-nitroacetophenone is a light beige powder. It is an anthropogenic compound which is used as a synthetic intermediate in the production of dyes and other organic compounds. (NTP, 1992)
Air & Water Reaktionen
Insoluble in water.
Reaktivität anzeigen
A nitrated ketone. Ketones are reactive with many acids and bases liberating heat and flammable gases (e.g., H2). The amount of heat may be sufficient to start a fire in the unreacted portion of the ketone. Ketones react with reducing agents such as hydrides, alkali metals, and nitrides to produce flammable gas (H2) and heat. Ketones are incompatible with isocyanates, aldehydes, cyanides, peroxides, and anhydrides. They react violently with aldehydes, HNO3, HNO3 + H2O2, and HClO4.
Brandgefahr
Flash point data for 3-Nitroacetophenone are not available, however 3-Nitroacetophenone is probably combustible.
läuterung methode
Distil the ketone in steam and crystallise it from EtOH. [Beilstein 7 IV 656.]

3-Nitroacetophenone Upstream-Materialien And Downstream Produkte

3'-Nitroacetophenon Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

121-89-1, 3-Nitroacetophenone Verwandte Suche:

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