Cholintheophyllinat

Gefahreninformationscode (GHS)

• Bildanzeige (GHS)

  

• Alarmwort

  Warnung

• Gefahrenhinweise

  H302：Gesundheitsschädlich bei Verschlucken.

CHOLINE THIEOPHYLLINATE Chemische Eigenschaften,Einsatz,Produktion Methoden

• Originator

  Sabidal ,S.R. Zyma, UK ,1983

• Verwenden

  Oxytrimethylline is used in the treatment for chronic asthma.

• Verwenden

  Bronchodilator.

• Manufacturing Process

  18 parts by weight of theophylline are added to 37.8 parts by weight of aqueous choline bicarbonate (47% assay) and the mixture stirred and heated at 80°C to 90°C until the evolution of carbon dioxide has ceased and complete solution effected. Water is separated from the reaction mixture by distillation under a vacuum sufficient to keep the still temperature between 50°C and 55 C. After about 95 parts by weight of water have been separated, about 80 parts by weight of isopropyl alcohol are added and the mixture subjected to further distillation under a vacuum sufficient to keep the mixture boiling at about 40°C. The distillation removes some of the water as an azeotrope with the isopropyl alcohol. During the removal of the water-isopropyl alcohol azeotrope a crystalline precipitate forms. The mixture is further cooled slowly to 5°C and the crystalline precipitate filtered off. The choline theophyllinate crystals are then washed with isopropyl alcohol and dried under vacuum at about 70°C. A second crop of the product may be obtained from the mother liquor by further reduction in volume and cooling. A yield of 90.5% of theory of choline theophyllinate is obtained completely free of inorganic salts.

• Trademarks

  Choledyl(Parke-Davis).

• Therapeutic Function

  Smooth muscle relaxant

CHOLINE THIEOPHYLLINATE Upstream-Materialien And Downstream Produkte

Cholintheophyllinat Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global(66)Suppliers

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