Diprophyllin

Gefahreninformationscode (GHS)

• Bildanzeige (GHS)

  

• Alarmwort

  Warnung

• Gefahrenhinweise

  H302：Gesundheitsschädlich bei Verschlucken.

Diprophylline Chemische Eigenschaften,Einsatz,Produktion Methoden

• R-Sätze Betriebsanweisung:

  R22:Gesundheitsschädlich beim Verschlucken.
  R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.

• S-Sätze Betriebsanweisung:

  S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
  S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
  S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.

• Beschreibung

  Dyphylline is the N-7 dihydroxypropyl derivative of theophylline and is not a theophylline salt. Dyphylline does not get metabolized to theophylline in vivo, and even though it contains 70% theophylline by molecular weight ratio, the equivalent amount to theophylline is not known. Dosing must be accomplished independently by monitoring dyphylline blood levels. Dyphylline has a diminished bronchodilator effect compared to theophylline, but it may have lower and less serious side effects. Dosage forms available are an elixir and tablets.

• Beschreibung

  Dyphylline is a xanthine derivative that acts as an A₁ and A₂ adenosine receptor antagonist and phosphodiesterase inhibitor and exhibits bronchodilator and vasodilator effects. It also moderately inhibits microsomal prostaglandin E synthase-1 with an IC₅₀ value of 200 μM and downregulates ABCG2 drug transporter expression in multidrug resistant tumor cells.

• Chemische Eigenschaften

  white to light yellow crystal powder

• Originator

  Neothylline,Lemmon,US,1948

• Verwenden

  An adenosine receptor antagonist, phosphodiesterase inhibitor and vasodilator

• Verwenden

  PDE inhibitor, bronchodilator, vasodilator

• Definition

  ChEBI: An oxopurine that is theophylline bearing a 2,3-dihydroxypropyl group at the 7 position. It has broncho- and vasodilator properties, and is used in the treatment of asthma, cardiac dyspnea, and bronchitis. It is also an ingredient in preparations that have been promoted for coughs.

• Manufacturing Process

  180 grams of theophylline is dissolved in 500 cc of boiling water. To this solution is added 40 grams of sodium hydroxide or 56 grams of potassium hydroxide slowly and with constant stirring.
  When solution is complete, 120 grams of 1-chloro-2,3-dihydroxypropane is slowly added. The thus provided mixture is brought to boiling and heating is continued until a temperature of 110°C is reached.
  The resultant liquid is evaporated under reduced pressure to remove all traces of water. The resulting syrupy liquid is allowed to stand with occasional stirring until crystallization takes place. The compound is purified by recrystallization from alcohol. The product melts at 155°-157°C.

• Trademarks

  Dilor (Savage); Lufyllin (Medpointe); Neothylline (Teva).

• Therapeutic Function

  Smooth muscle relaxant

• Biochem/physiol Actions

  7-(2,3-Dihydroxypropyl)theophylline is also called as dyphylline. Dyphylline serves as a bronchodilator and aids in better air flow through the lungs. It reduces the symptoms of chronic lung disorder such as asthma and bronchitis.

Diprophylline Upstream-Materialien And Downstream Produkte

Diprophyllin Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global(400)Suppliers

479-18-5, Diprophylline Verwandte Suche: