3,7-Dihydro-7-(2-hydroxypropyl)-1,3-dimethyl-1H-purin-2,6-dion

Bezeichnung:3,7-Dihydro-7-(2-hydroxypropyl)-1,3-dimethyl-1H-purin-2,6-dion

CAS-Nr603-00-9

Englisch Name:PROXYPHYLLINE

CBNumberCB7492824

SummenformelC10H14N4O3

Molgewicht238.24

MOL-Datei603-00-9.mol

Synonyma

Proxyphyllin

3,7-Dihydro-7-(2-hydroxypropyl)-1,3-dimethyl-1H-purin-2,6-dion

3,7-Dihydro-7-(2-hydroxypropyl)-1,3-dimethyl-1H-purin-2,6-dion physikalisch-chemischer Eigenschaften

Schmelzpunkt	134-136°C
Siedepunkt	487.2±51.0 °C(Predicted)
Dichte	1.46±0.1 g/cm3(Predicted)
storage temp.	Inert atmosphere,Room Temperature
pka	14.55±0.20(Predicted)
Aggregatzustand	Solid
Farbe	White to Off-White
Wasserlöslichkeit	285.7g/L(temperature not stated)
Merck	14,7905
InChI	InChI=1S/C10H14N4O3/c1-6(15)4-14-5-11-8-7(14)9(16)13(3)10(17)12(8)2/h5-6,15H,4H2,1-3H3
InChIKey	KYHQZNGJUGFTGR-UHFFFAOYSA-N
SMILES	N1(CC(O)C)C2=C(N(C)C(=O)N(C)C2=O)N=C1
CAS Datenbank	603-00-9(CAS DataBase Reference)
NIST chemische Informationen	Proxyphylline(603-00-9)

Sicherheit

Kennzeichnung gefährlicher	Xn
R-Sätze:	22
S-Sätze:	36
WGK Germany	3
RTECS-Nr.	XH5907500
HS Code	2939.59.0000

Gefahreninformationscode (GHS)

PROXYPHYLLINE Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R22:Gesundheitsschädlich beim Verschlucken.
S-Sätze Betriebsanweisung:
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Chemische Eigenschaften
White Solid
Verwenden
A metabolite of Theophylline in human plasma.
Definition
ChEBI: Proxyphylline is an oxopurine.
Biologische Aktivität
ki: 82 nm for bovine brain a1 adenosine receptorproxyphylline is an a1 adenosine receptor antagonist.the a1 adenosine receptor, the best characterized purinergic receptor family, can mediate responses via multiple pertussis toxin-sensitive gtp binding proteins to various different effectors.
in vitro
previous study showed that proxyphylline could selectively antagonize a1 adenosine receptors versus a2 adenosine receptors (ki = 850 μm for platelets) [1].
in vivo
in a previous study, rats that were allodynic following the vincristine injections were randomly allocated into four groups. theoesberiven f (a combination of proxyphylline and melilotus extract) was administered to rats. results showed that the decreased paw withdrawal threshold induced by vincristine injection was increased by theoesberiven f treatment and the increased withdrawal frequency to cold stimuli was also reduced by theoesberiven f treatment [2].
läuterung methode
Crystallise it from EtOH, aqueous MeOH or EtOAc. Roth Archiv Pharmazie 292 234 1959, Zelnik et al. Bull Soc Chim Fr 1733 1956, Beilstein 26 III/IV 2366.]
Einzelnachweise
[1] u. schwabe, d. ukena and m. j. lohse. xanthine derivatives as antagonists at a1 and a2 adenosine receptors. naunyn-schmiedeberg's arch.pharmacol. 330,212-221 (1985).
[2] s. bang, y. s. kim and s. r. jeong. anti-allodynic effect of theoesberiven f in a vincristine-induced neuropathy model. exp. ther. med. 12(2), 799-803 (2016).
[3] selvig k. pharmacokinetics of proxyphylline in adults after intravenous and oral administration. eur j clin pharmacol. 1981 jan;19(2):149-55.

3,7-Dihydro-7-(2-hydroxypropyl)-1,3-dimethyl-1H-purin-2,6-dion Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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