(E)-p-Methoxycinnamsure

Bezeichnung:(E)-p-Methoxycinnamsure

CAS-Nr943-89-5

Englisch Name:4-METHOXYCINNAMIC ACID

CBNumberCB1152939

SummenformelC10H10O3

Molgewicht178.18

MOL-Datei943-89-5.mol

Synonyma

(E)-p-Methoxycinnamsure

(E)-p-Methoxycinnamsure physikalisch-chemischer Eigenschaften

Schmelzpunkt	173.5 °C(lit.)
Siedepunkt	342.6±17.0 °C(Predicted)
Dichte	1.195±0.06 g/cm3(Predicted)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
Löslichkeit	Soluble in ethanol, ethyl acetate and other organic solvents.
pka	4.60±0.10(Predicted)
Aggregatzustand	powder to crystal
Farbe	White to Almost white
BRN	510468
InChIKey	AFDXODALSZRGIH-QPJJXVBHSA-N
LogP	1.264 (est)
CAS Datenbank	943-89-5(CAS DataBase Reference)
NIST chemische Informationen	2-Propenoic acid, 3-(4-methoxyphenyl)-, (e)-(943-89-5)
EPA chemische Informationen	2-Propenoic acid, 3-(4-methoxyphenyl)-, (2E)- (943-89-5)

Sicherheit

Kennzeichnung gefährlicher	Xi
R-Sätze:	36/37/38
S-Sätze:	26-37/39
WGK Germany	3
RTECS-Nr.	UD3391300
F	8
TSCA	Yes
HS Code	2918.29.7500
HazardClass	IRRITANT

Gefahreninformationscode (GHS)

4-METHOXYCINNAMIC ACID Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S37/39:Bei der Arbeit geeignete Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
Verwenden
Esters derived from trans-4-methoxycinnamic acid are effective absorbers of UV radiation. The starting material was trans-4-methoxycinnamic acid and 3,5dimethoxybenzoic acid methyl ester in isolated avenanthramide alkaloids synthsis. trans-4-Methoxycinnamic acid was converted into its acid chloride (yield 98%) with thionyl chloride. Employed in organic synthesis of pharmaceutical intermediates, synthetic anti-adrenergic drugs esmolol, cosmetics ultraviolet absorption.
synthetische
4-methoxycinnamic acid synthesis : In a 25-mL, roundbottomed flask, 4-methoxybenzaldehyde (0.804 mL, 6.61 mmol) (3), malonic acid (1.75 g, 16.8 mmol), and β-alanine (0.10 g, 1.12 mmol) were dissolved in pyridine (3.0 mL, 37.1 mmol) and heated under reflux for 90 minutes. After cooling to room temperature, the reaction mixture was placed in an ice bath and 8.0 mL of concentrated HCl was slowly added. The resulting white precipitate was collected by vacuum filtration, washed with cold water (2 x 10mL) and dried thoroughly. The product was recrystallized from absolute ethanol (~20 mL).
Synthesis of 4-methoxycinnamic acid
Definition
ChEBI: 4-methoxycinnamic acid is a methoxycinnamic acid having a single methoxy substituent at the 4-position on the phenyl ring. It is functionally related to a cinnamic acid.
läuterung methode
Crystallise the acid from MeOH to constant melting point and UV spectrum. [Beilstein 10 IV 1005.]

4-METHOXYCINNAMIC ACID Upstream-Materialien And Downstream Produkte

(E)-p-Methoxycinnamsure Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

943-89-5, 4-METHOXYCINNAMIC ACID Verwandte Suche:

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