9-Oxo-10(9H)-acridineacetic acid

Bezeichnung:9-Oxo-10(9H)-acridineacetic acid

CAS-Nr38609-97-1

Englisch Name:9-Oxo-10(9H)-acridineacetic acid

CBNumberCB0502504

SummenformelC15H11NO3

Molgewicht253.25

MOL-Datei38609-97-1.mol

9-Oxo-10(9H)-acridineacetic acid physikalisch-chemischer Eigenschaften

Schmelzpunkt	~289 °C (dec.)
Siedepunkt	486.6±34.0 °C(Predicted)
Dichte	1.362
storage temp.	Sealed in dry,Room Temperature
Löslichkeit	Aqueous Base (Slightly), DMSO (Slightly)
Aggregatzustand	Solid
pka	3.69±0.10(Predicted)
Farbe	Pale Yellow to Light Yellow
maximale Wellenlänge (λmax)	410nm(H2O)(lit.)
BRN	227508
InChI	InChI=1S/C15H11NO3/c17-14(18)9-16-12-7-3-1-5-10(12)15(19)11-6-2-4-8-13(11)16/h1-8H,9H2,(H,17,18)
InChIKey	UOMKBIIXHQIERR-UHFFFAOYSA-N
SMILES	C1=C2C(N(CC(O)=O)C3=C(C2=O)C=CC=C3)=CC=C1
CAS Datenbank	38609-97-1(CAS DataBase Reference)

Sicherheit

Kennzeichnung gefährlicher	Xi
R-Sätze:	36/37/38
S-Sätze:	26
WGK Germany	3
RTECS-Nr.	AR7190000
HS Code	2933.99.8290

Gefahreninformationscode (GHS)

9-Oxo-10(9H)-acridineacetic acid Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
Definition
Acriridone derivatives have become a research hotspot in the field of medicine in recent years due to their good antibacterial, anti-inflammatory, anti-malarial, and anti-cancer activities. This type of compound has a rigid planar structure of a macrocyclic conjugated system and can be embedded or Electrostatic attraction binds to DNA. Among them, 9-aminoacridine derivatives have good pharmacological and biological activities, and some of them have been used clinically as DNA embedding reagents. As an important pharmaceutical intermediate, 9-Oxo-10(9H)-acridineacetic acid has also received increasing attention. Cridanimod (9-Oxo-10(9H)-acridineacetic acid) is a potent progesterone receptor (PR) activator mediated through induction of IFNα and IFNβ expression. Cridanimod is a small-molecule immunomodulator and interferon inducer.
Beschreibung
9-Oxo-10(9H)-acridineacetic acid , also known as Cridanimod or XBIO-101, is a small molecule that can increase progesterone receptor (PR) expression, with potential antineoplastic adjuvant activity. Cridanimod is able to induce the expression of PR in endometrial cancer. This could increase the sensitivity of endometrial cancer cells to progestin monotherapy. In combination with a progestin, cancer cells could be eradicated through increased PR-mediated signaling, leading to an inhibition of luteinizing hormone (LH) release from the pituitary gland, via a negative feedback mechanism, and, eventually, an inhibition of estrogen release from the ovaries. This leads to an inhibition of cellular growth in estrogen-dependent tumor cells.
Verwenden
9-Oxo-10(9H)-acridineacetic acid is a reagent for pre-column derivatization of amino acids for fluorescent determination in HPLC and it is also a building block in pharmaceutics.
Definition
ChEBI: Cridanimod is a member of acridines. It is functionally related to an acridone.
Lager
Store at +4°C

9-Oxo-10(9H)-acridineacetic acid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

38609-97-1, 9-Oxo-10(9H)-acridineacetic acid Verwandte Suche:

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