Amsacrine hydrochloride Struktur

Amsacrine hydrochloride

Bezeichnung:Amsacrine hydrochloride

CAS-Nr54301-15-4

Englisch Name:Amsacrine hydrochloride

CBNumberCB4236395

SummenformelC21H20ClN3O3S

Molgewicht429.92

MOL-Datei54301-15-4.mol

Amsacrine hydrochloride physikalisch-chemischer Eigenschaften

Schmelzpunkt	197-199 °C(lit.)
storage temp.	Refrigerator
Löslichkeit	DMSO: 10 mg/mL with heat and sonication
Aggregatzustand	powder
Farbe	red to brown

Sicherheit

Kennzeichnung gefährlicher	T
R-Sätze:	25-36/37/38
S-Sätze:	26-45
RIDADR	UN 2811 6.1/PG 3
WGK Germany	3
RTECS-Nr.	PB1081000
HS Code	2933.99.8290
HazardClass	6.1(b)
PackingGroup	III

Gefahreninformationscode (GHS)

Amsacrine hydrochloride Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R25:Giftig beim Verschlucken.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
Verwenden
Amsacrine hydrochloride has been used:
- as a topoisomerase poison in bacteriophage T4 topoisomerase assay
- as a topoisomerase inhibitor in Drosophila cell line, Kc167
- as an antileukemia drug to test its effect on p53 transcriptional activity in tumor xenografts
- as a topoisomerase II poison in dose-response assays in C elegans
Biologische Aktivität
amsacrine hydrochloride (amsidine, m-amsa) is an inhibitor of topoisomerase 2 [1].amsacrine hydrochloride is a chemotherapy drug of antineoplastic, used to treat some types of lymphoma and acute leukaemia. in addition, amsacrine hydrochloride has shown the sensitivities to the cancer cell lines with the ic50 values of 190.2±27.4ng/ml, 46.1±3.9ng/ml,22.6±3.1ng/ml, 11.8±2.0ng/ml, 5.0±0.4ng/ml, and 11.7±1.5ng/ml for three bladder cancer cell lines (ht1376,rt112, rt4) and three testis cancer cell lines(833k, susa, gh), respectively. and it has been found that the testis tumor cell lines are more sensitive to inhibiting by amsacrine hydrochloride than the bladder cell lines [1].
Biochem/physiol Actions
Amsacrine (m-AMSA) is a derivative of acridine and an antileukemia drug. It is an anticancer drug with antineoplastic activity that targets topoisomerase II. AMSA is an apoptosis inducer and favors the accumulation of double-stranded breaks (DSBs). It also inhibits the expression of matrix metallopeptidase 2 (MMP-2) and MMP-9 expression in leukemia cells by generating reactive oxygen species (ROS). AMSA serves as an adjuvant in trabeculectomy surgery.
Einzelnachweise
[1] nelson em, tewey km, liu lf. mechanism of antitumor drug action: poisoning of mammalian dna topoisomerase ii on dna by 4'-(9-acridinylamino)-methanesulfon-m-anisidide. proc natl acad sci u s a. 1984 mar;81(5):1361-5.

Amsacrine hydrochloride Upstream-Materialien And Downstream Produkte

Amsacrine hydrochloride Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

54301-15-4, Amsacrine hydrochloride Verwandte Suche:

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