生物活性 体外研究 体内研究 盐酸胡芦巴碱 试剂级价格
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盐酸胡芦巴碱

盐酸胡芦巴碱,6138-41-6,结构式
盐酸胡芦巴碱
  • CAS号:6138-41-6
  • 英文名:Trigonelline hydrochloride
  • 中文名:盐酸胡芦巴碱
  • CBNumber:CB9168394
  • 分子式:C7H8ClNO2
  • 分子量:173.6
  • MOL File:6138-41-6.mol
盐酸胡芦巴碱化学性质
  • 熔点 :~260 °C (dec.)
  • 储存条件 :Inert atmosphere,Room Temperature
  • 溶解度 :Methanol (Slightly), Water
  • 形态 :Solid
  • 颜色 :White to Off-White
  • Merck :14,9694
  • BRN :3734169
  • 稳定性 :Hygroscopic
  • CAS 数据库 :6138-41-6(CAS DataBase Reference)
安全信息

盐酸胡芦巴碱性质、用途与生产工艺

  • 生物活性 Trigonelline chloride 是一种大量存在于咖啡中并且具有潜在抗糖尿病活性的生物碱。Trigonelline chloride 具有抗 HSV-1,抗菌和抗真菌活性。
  • 体外研究

    It is found that Trigonelline chloride (TG) significantly rescues the morphology of the H9c2 cells. Treatment of cells with Trigonelline chloride attenuates H 2 O 2 induced cell deaths and improves the antioxidant activity. In addition, Trigonelline chloride regulates the apoptotic gene caspase-3, caspase-9 and anti-apoptotic gene Bcl-2, Bcl-XL during H 2 O 2 induced oxidative stress in H9c2 cells. For evident, flow cytometer results also confirm that Trigonelline chloride significantly reduces the H 2 O 2 induced necrosis and apoptosis in H9c2 cells. However, further increment of Trigonelline chloride concentration against H 2 O 2 can induce the necrosis and apoptosis along with H 2 O 2 .

  • 体内研究

    Trigonelline chloride decreases bone mineralization and tends to worsen bone mechanical properties in streptozotocin-induced diabetic rats. In nicotinamide/streptozotocin-treated rats, Trigonelline chloride significantly increases bone mineral density (BMD) and tends to improve cancellous bone strength. Trigonelline chloride differentially affects the skeletal system of rats with streptozotocin-induced metabolic disorders, intensifying the osteoporotic changes in streptozotocin-treated rats and favorably affecting bones in the non-hyperglycemic (nicotinamide/streptozotocin-treated) rats.

  • 化学性质  可溶于甲醇、乙醇、DMSO等有机溶剂,来源于葫芦巴。
  • 用途  盐酸葫芦巴碱具有降血糖的作用。
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盐酸胡芦巴碱 试剂级价格
  • 更新日期:2024/11/08
  • 产品编号:HY-N0415
  • 产品名称:盐酸胡芦巴碱 Trigonelline chloride
  • CAS编号:6138-41-6
  • 包装:100mg
  • 价格:500元
  • 更新日期:2024/11/08
  • 产品编号:HY-N0415
  • 产品名称:盐酸胡芦巴碱 Trigonelline chloride
  • CAS编号:6138-41-6
  • 包装:10mM * 1mLin DMSO
  • 价格:550元
盐酸胡芦巴碱生产厂家
  • 公司名称:Service Chemical Inc.
  • 联系电话:--
  • 电子邮件:sales@chemos-group.com
  • 国家:德国
  • 产品数:6350
  • 优势度:71
  • 公司名称:ABCR
  • 联系电话:--
  • 电子邮件:info@abcr.de
  • 国家:德国
  • 产品数:6831
  • 优势度:75
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