葫芦巴碱

生物活性靶点体外研究体内研究葫芦巴碱试剂级价格

葫芦巴碱

CAS号:535-83-1
英文名:Trigonelline
中文名:葫芦巴碱
CBNumber:CB4415552
分子式:C7H7NO2
分子量:137.14
MOL File:535-83-1.mol

葫芦巴碱化学性质

熔点 :260°C (dec.)
沸点 :251.96°C (rough estimate)
密度 :1.2528 (rough estimate)
折射率 :1.5030 (estimate)
储存条件 :Refrigerator
溶解度 :Methanol (Slightly), Water (Slightly)
形态 :Solid
颜色 :Off-White to Light Beige
InChI :InChI=1S/C7H7NO2/c1-8-4-2-3-6(5-8)7(9)10/h2-5H,1H3
InChIKey :WWNNZCOKKKDOPX-UHFFFAOYSA-N
SMILES :C1(C([O-])=O)=CC=C[N+](C)=C1
LogP :-3.910 (est)

安全信息

安全说明 :24/25
海关编码 :29339900
毒害物质数据 :535-83-1(Hazardous Substances Data)

葫芦巴碱性质、用途与生产工艺

生物活性 Trigonelline (Trigenolline) 是一种植物生物碱，是咖啡和葫芦巴的主要成分，具有抗脱粒、抗糖尿病、抗氧化、抗炎和神经保护的作用。 Trigonelline 可抑制FcεRI介导的细胞内信号通路，例如 PLCγ1、PI3K 和 Akt 的磷酸化。Trigonelline (Trigenolline) 还可抑制RBL-2H3细胞中 microtubule 的形成。
靶点
Target Value
PLCγ1
()
PI3K
()
Akt
()
microtubule
()
体外研究

It is found that Trigonelline (TG) significantly rescues the morphology of the H9c2 cells. Treatment of cells with Trigonelline attenuates H ₂ O ₂ induced cell deaths and improves the antioxidant activity. In addition, Trigonelline regulates the apoptotic gene caspase-3, caspase-9 and anti-apoptotic gene Bcl-2, Bcl-XL during H ₂ O ₂ induced oxidative stress in H9c2 cells. For evident, flow cytometer results also confirms that Trigonelline significantly reduces the H ₂ O ₂ induced necrosis and apoptosis in H9c2 cells. However, further increment of Trigonelline concentration against H ₂ O ₂ can induce the necrosis and apoptosis along with H ₂ O ₂ .
体内研究

Trigonelline decreases bone mineralization and tends to worsen bone mechanical properties in streptozotocin-induced diabetic rats. In nicotinamide/streptozotocin-treated rats, Trigonelline significantly increases bone mineral density (BMD) and tends to improve cancellous bone strength. Trigonelline differentially affects the skeletal system of rats with streptozotocin-induced metabolic disorders, intensifying the osteoporotic changes in streptozotocin-treated rats and favorably affecting bones in the non-hyperglycemic (nicotinamide/streptozotocin-treated) rats.
化学性质白色结晶性粉末，溶于甲醇和水，来源于葫芦巴、使君子，大豆。
用途用于含量测定/鉴定/药理实验等。
药理药效:为胡芦巴中的主要成分，具有抗肿瘤作用。
用途用作营养型添加剂，医药中间体