葫芦巴碱
葫芦巴碱 性质
| 熔点 | 260°C (dec.) |
|---|---|
| 沸点 | 251.96°C (rough estimate) |
| 密度 | 1.2528 (rough estimate) |
| 折射率 | 1.5030 (estimate) |
| 储存条件 | Refrigerator |
| 溶解度 | 甲醇（微溶）、水（微溶） |
| 形态 | 固体 |
| 颜色 | 灰白色至浅米色 |
| InChI | InChI=1S/C7H7NO2/c1-8-4-2-3-6(5-8)7(9)10/h2-5H,1H3 |
| InChIKey | WWNNZCOKKKDOPX-UHFFFAOYSA-N |
| SMILES | C1(C([O-])=O)=CC=C[N+](C)=C1 |
| LogP | -3.910 (est) |
葫芦巴碱 用途与合成方法
| Target | Value |
|
PLCγ1
() | |
|
PI3K
() | |
|
Akt
() | |
|
microtubule
() |
It is found that Trigonelline (TG) significantly rescues the morphology of the H9c2 cells. Treatment of cells with Trigonelline attenuates H 2 O 2 induced cell deaths and improves the antioxidant activity. In addition, Trigonelline regulates the apoptotic gene caspase-3, caspase-9 and anti-apoptotic gene Bcl-2, Bcl-XL during H 2 O 2 induced oxidative stress in H9c2 cells. For evident, flow cytometer results also confirms that Trigonelline significantly reduces the H 2 O 2 induced necrosis and apoptosis in H9c2 cells. However, further increment of Trigonelline concentration against H 2 O 2 can induce the necrosis and apoptosis along with H 2 O 2 .
Trigonelline decreases bone mineralization and tends to worsen bone mechanical properties in streptozotocin-induced diabetic rats. In nicotinamide/streptozotocin-treated rats, Trigonelline significantly increases bone mineral density (BMD) and tends to improve cancellous bone strength. Trigonelline differentially affects the skeletal system of rats with streptozotocin-induced metabolic disorders, intensifying the osteoporotic changes in streptozotocin-treated rats and favorably affecting bones in the non-hyperglycemic (nicotinamide/streptozotocin-treated) rats.
药理药效:为胡芦巴中的主要成分，具有抗肿瘤作用。
葫芦巴碱 价格(试剂级)
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024-11-08 | HY-N0414 | 5 mg | 430 | ||
| 2024-11-08 | HY-N0414 | 葫芦巴碱 | 535-83-1 | 10mg | 700 |
