143797-62-0
基本信息
化合物SB-200646A
1-(1-甲基-1H-吲哚-5-基)-3-(吡啶-3-基)脲盐酸盐
SB 200646 HYDROCHLORIDE,5-HT2C/2B RECEPTOR拮抗剂
SB 200646A,SB200646A
SB 200646 hydrochloride, 5-HT2C/2B receptor antagonist
物理化学性质
| 储存条件 | Inert atmosphere,Room Temperature |
| 溶解度 | DMSO: ~26 mg/mL, soluble |
| 形态 | solid |
| 颜色 | pale yellow |
安全数据
| 危险性符号(GHS) |  GHS07 |
| 警示词 | 警告 |
| 危险性描述 | H335-H315-H319 |
| 防范说明 | P264-P280-P305+P351+P338-P337+P313P-P264-P280-P302+P352-P321-P332+P313-P362 |
| 危险品标志 | Xi |
| 危险类别码 | 36/37/38 |
| 安全说明 | 26-36 |
| WGK Germany | 3 |
1-(1-甲基-1H-吲哚-5-基)-3-(吡啶-3-基)脲盐酸盐价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2026/09/15 | HY-103129 | 1-(1-甲基-1H-吲哚-5-基)-3-(吡啶-3-基)脲盐酸盐 SB-200646A | 143797-62-0 | 5mg | 700元 |
| 2026/09/15 | HY-103129 | 1-(1-甲基-1H-吲哚-5-基)-3-(吡啶-3-基)脲盐酸盐 SB-200646A | 143797-62-0 | 10mM * 1mLin DMSO | 770元 |
| 2026/09/15 | HY-103129 | 1-(1-甲基-1H-吲哚-5-基)-3-(吡啶-3-基)脲盐酸盐 SB-200646A | 143797-62-0 | 10mg | 1100元 |
常见问题列表
|
5-HT 2B Receptor 7.5 (pKi) |
5-HT 2C Receptor 6.9 (pKi) |
5-HT 2A Receptor 5.2 (pKi) |
SB200646A (4 μM) abolishes the ethanol-induced increase in miniature inhibitory postsynaptic current (mIPSC) frequency and had no effect on basal mIPSC frequency.
SB-200646A (20 mg/kg; intravenous injection; daily; for 21 days; male albino Sprague-Dawley rats) treatment significantly decreases the number of spontaneously active ventral tegmental area (VTA) dopaminergic neurons.
The i.v. administration of 4-16 mg/kg of SB-200646A significantly increases the firing rate and % events as bursts in spontaneously active VTA dopaminergic neurons and significantly increases the % events as burst in substantia nigra pars compacta (SNC) dopaminergic neurons.
| Animal Model: | Male albino Sprague-Dawley rats (200-225 g at the beginning of treatment and 300-350 g at the time of the experiment) |
| Dosage: | 20 mg/kg |
| Administration: | Intravenous injection; daily; for 21 days |
| Result: | Significantly decreased the number of spontaneously active ventral tegmental area (VTA) dopaminergic neurons. |