First aid
If this chemical gets into the eyes, remove any
contact lenses at once and irrigate immediately for at least
15 minutes, occasionally lifting upper and lower lids. Seek
medical attention immediately. If this chemical contacts the
skin, remove contaminated clothing and wash immediately
with soap and water. Seek medical attention immediately.
If this chemical has been inhaled, remove from exposure,
begin rescue breathing (using universal precautions) if
breathing has stopped, and CPR if heart action has stopped.
Transfer promptly to a medical facility. When this chemical
has been swallowed, get medical attention. Give large
quantities of water and induce vomiting. Do not make an
unconscious person vomit. Do not induce vomiting when
formulations containing petroleum solvents are ingested
Shipping
UN3082 Environmentally hazardous substances,
liquid, n.o.s., Hazard class: 9; Labels: 9-Miscellaneous haz ardous material, Technical Name Required.
Description
Flumetsulam is a selective, post-emergence herbicide used mainly to control broadleaved weeds and some grasses. It is highly soluble in water and has a low volatility. It can be moderately persistent in some soil systems and very persistent, depending on conditions, in water bodies. There is a significant potential for it to leach to groundwaters. Its mammalian oral toxicity is low and it can be an irritant for skin and eyes. Other data related to chronic health is missing. Generally, it has a low toxicity for most biodiversity.
Chemical Properties
Brown SOlid
Chemical Properties
Flumetsulam is a colorless liquid which
does not exist as a free, pure substance. Used as an
aqueous solution.
Waste Disposal
Must be disposed properly by
following package label directions or by contacting your
local or federal environmental control agency, or by con tacting your regional EPA office. If this material cannot be
disposed of according to label instructions, it may be dis solved or mixed with a combustible solvent and burned in
a chemical incinerator equipped with an afterburner and
scrubber. In accordance with 40CFR165, follow recommen dations for the disposal of pesticides and pesticide contain ers. Noncombustible containers should be crushed and
buried under more than 40 cm of soil.
Uses
Flumetsulam is a ighly active herbicide of the triazolopyrimidine sulfonanilide class. Flumetsulam act by inhibiting acetolactate synthase. Flumetsulam exhibits broad spectrum activity on broadleaf weed species with selectivity to several major agronomic crops in soil and foliar applications.
Definition
ChEBI: Flumetsulam is a sulfonamide.
Production Methods
Flumetsulam is commercially produced through a multi-step synthesis that constructs its complex heterocyclic structure. The process typically begins with the formation of a substituted pyrimidine ring, which is then functionalised with a sulfonamide group and a difluorophenyl moiety. Key intermediates include 5-methyltriazolo[1,5-a]pyrimidine and 2,6-difluoroaniline, which are coupled under controlled conditions using chlorosulfonic acid or similar reagents to form the sulfonamide linkage. The reactions are carried out in organic solvents under regulated temperature and pH to ensure high yield and purity.
Mechanism of action
Selective, systemic, absorbed by roots and leaves. Inhibits plant amino acid synthesis - acetohydroxyacid synthase AHAS.
Toxics Screening Level
The initial threshold screening level (ITSL) for flumetsulam is 26 μg/m3 based on an annual averaging time.
