83366-66-9

Crystalline Solid

Dutonin,Bristol-Myers Squibb,USA

A selective serotonin 5-HT2 receptor antagonist. An antidepressant

ChEBI: Nefazodone is a N-arylpiperazine, a N-alkylpiperazine, a member of triazoles, a member of monochlorobenzenes and an aromatic ether. It has a role as an antidepressant, a serotonergic antagonist, a serotonin uptake inhibitor, an alpha-adrenergic antagonist and an analgesic.

Serzone (Bristol-Myers Squibb).

Antidepressant

Although nefazodone (Serzone) is structurally related to trazodone, it is less sedating. It does not block α₁- adrenoreceptors, and its use is not associated with priapism. Nefazodone inhibits the neuronal reuptake of serotonin and blocks 5HT2A receptors. Its short half-life requires dosing twice a day. Nefazodone is not associated with weight gain or sexual dysfunction. It inhibits the cytochrome P450 3A4 isoenzyme that is responsible for 50% of known oxidative metabolism, and therefore, nefazodone can elevate levels of drugs dependent on this pathway for metabolism.