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1-Bromo-3-chloropropane Basic information
1-Bromo-3-chloropropane Chemical Properties
  • Melting point:-59 °C
  • Boiling point:144-145 °C (lit.)
  • Density 1.592 g/mL at 25 °C (lit.)
  • vapor pressure 7.5 hPa (20 °C)
  • refractive index n20/D 1.486(lit.)
  • Flash point:81 °C
  • storage temp. room temp
  • solubility 2.24g/l insoluble
  • form liquid
  • color Clear liquid
  • explosive limit3.2-8.6%(V)
  • Water Solubility insoluble
  • BRN 605278
  • CAS DataBase Reference109-70-6(CAS DataBase Reference)
  • IARC2B (Vol. 125)
  • NIST Chemistry ReferencePropane, 1-bromo-3-chloro-(109-70-6)
  • EPA Substance Registry SystemPropane, 1-bromo-3-chloro- (109-70-6)
Safety Information
1-Bromo-3-chloropropane Usage And Synthesis
  • Chemical Propertiesclear liquid
  • Uses1-Bromo-3-chloropropane can be used safer and equally efficient alternative to chloroform as a phase-separation agent in the 1-step method of RNA isolation from biological samples such as animal and p lant tissue.
  • UsesA replacement for CHCl3 in RNA phase separations
  • General DescriptionA colorless liquid. Insoluble in water and denser than water. May be toxic by inhalation, ingestion or skin absorption. Used to make pharmaceuticals and other chemicals.
  • Air & Water ReactionsInsoluble in water.
  • Reactivity ProfileHalogenated aliphatic compounds, such as 1-Bromo-3-chloropropane, are moderately or very reactive. Reactivity generally decreases with increased degree of substitution of halogen for hydrogen atoms. Materials in this group are incompatible with strong oxidizing and reducing agents. Also, they are incompatible with many amines, nitrides, azo/diazo compounds, alkali metals, and epoxides.
  • Health HazardInhalation of vapors or dust is extremely irritating. May cause burning of eyes and flow of tears. May cause coughing, difficult breathing and nausea. Brief exposure effects last only a few minutes. Exposure in an enclosed area may be very harmful. Fire will produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may cause pollution.
  • Fire HazardSome of these materials may burn, but none ignite readily. Containers may explode when heated.
  • Safety ProfileModerately toxic by ingestion. When heated to decomposition it emits toxic fumes of Cland Br-. See also CHLORINATED HYDROCARBONS, ALIPHATIC; and BROMIDES.
  • Purification MethodsWash it with conc H2SO4, water, 10% Na2CO3 solution, water again and then dry with CaCl2 and fractionally distil it just before use [Akagi et al. J Am Chem Soc 78 4034 1956]. [Beilstein 1 H 109, 1 IV 212.]
1-Bromo-3-chloropropane Preparation Products And Raw materials
1-Bromo-3-chloropropane(109-70-6)Related Product Information
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