4,5-Dimethoxy-1-benzocyclobutenecarbonitrile is used in the preparation of selective bradycardic agents.
4,5-Dimethoxy-1-cyanobenzocyclobutane is used in the preparation of selective bradycardic agents.
NaNH2 (39.0 g,
1.0 mol) was added in portions to a solution of hydrocinnamonitrile
8 (224.0 g, 0.83 mol) in liquid ammonia at -45°C, and the reaction
mixture was stirred at -45 °C for 2 h. After evaporation of the excess
NH3, NH4Cl (20.0 g) and water (1000 mL) were added in portions.
After standing at room temperature, greyish crystals separated
and were collected and recrystallised with ethanol to give 4,5-Dimethoxy-1-cyanobenzocyclobutane as a colourless powder. Yield 116.5 g (74%).
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[3] Patent: US2014/107334, 2014, A1. Location in patent: Paragraph 0048-0051
[4] Patent: US2014/128598, 2014, A1. Location in patent: Paragraph 0040-0043
[5] Patent: US2014/163220, 2014, A1. Location in patent: Paragraph 0034-0037
