ChemicalBook CAS DataBase List 7087-68-5

7087-68-5

Name	Ethyldiisopropylamine
CAS	7087-68-5
EINECS(EC#)	230-392-0
Molecular Formula	C8H19N
MDL Number	MFCD00008868
Molecular Weight	129.24
MOL File	7087-68-5.mol

Synonyms

3-METHYL-1-BUTINE-3-OL DIEA DIISOPROPYLETHYLAMINE DIPEA edia ETHYLDIISOPROPYLAMINE HUENIGS BASE HUENIG'S BASE HUNIGS BASE 'HUNIG'S BASE' HUNIG'S BASE N-ETHYLDIISOPROPYLAMINE N-ETHYLDISSOPROPLYAMINE N,N'-DIISOPROPYLETHYLAMINE N,N-DIISOPROPYLETHYLAMINE (CH3)2CHN(C2H5)CH(CH3)2 1,1’-Dimethyltriethylamine 1,1'-Dimethyltriethylamine 2-Propanamine, N-ethyl-N-(1-methylethyl)- 2-Propanamine,N-ethyl-N-(1-methylethyl)-

Chemical Properties

Appearance	Clear, colorless to light yellow liquid
Melting point	<-50 °C (lit.)
Boiling point	127 °C (lit.)
density	0.782
vapor pressure	31 mmHg ( 37.7 °C)
refractive index	n20/D 1.457
Fp	6 °C
storage temp.	Store in dark!
solubility	miscible
form	Liquid
pka	10.98±0.28(Predicted)
color	APHA: <20
Specific Gravity	0.755 (20/4℃)
PH	12.3 (H2O, 20℃)(as an emulsion)
explosive limit	0.7-6.3%(V)
Water Solubility	miscible
Detection Methods	GC,NMR
BRN	605301
Stability:	Volatile
InChI	1S/C8H19N/c1-6-9(7(2)3)8(4)5/h7-8H,6H2,1-5H3
InChIKey	JGFZNNIVVJXRND-UHFFFAOYSA-N
SMILES	CCN(C(C)C)C(C)C
LogP	-1.8 at 22.5℃
CAS DataBase Reference	7087-68-5(CAS DataBase Reference)
NIST Chemistry Reference	(i-C3H7)2(C2H5)N(7087-68-5)
EPA Substance Registry System	7087-68-5(EPA Substance)

Safety Data

Symbol(GHS)	GHS02,GHS05,GHS06,GHS09
Signal word	Danger
Hazard statements	H225-H302-H318-H331-H335-H411
Precautionary statements	P210-P273-P280-P301+P312-P304+P340+P311-P305+P351+P338
Hazard Codes	C,F
Risk Statements	R11:Highly Flammable. R22:Harmful if swallowed. R34:Causes burns. R52/53:Harmful to aquatic organisms, may cause long-term adverse effects in the aquatic environment . R20/21/22:Harmful by inhalation, in contact with skin and if swallowed . R10:Flammable. less more
Safety Statements	S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice . S36/37/39:Wear suitable protective clothing, gloves and eye/face protection . S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) . S61:Avoid release to the environment. Refer to special instructions safety data sheet . S16:Keep away from sources of ignition-No smoking . S27:Take off immediately all contaminated clothing . S60:This material and/or its container must be disposed of as hazardous waste . S23:Do not breathe gas/fumes/vapor/spray (appropriate wording to be specified by the manufacturer) . less more
RIDADR	UN 2734 8/PG 2
WGK Germany	2
F	9-34
Autoignition Temperature	240 °C
Hazard Note	Highly Flammable/Corrosive/Harmful
TSCA	Yes
REACH Registrations	Active
HazardClass	3
PackingGroup	II
HS Code	29211980
Storage Class	3 - Flammable liquids
Hazard Classifications	Acute Tox. 3 Inhalation Acute Tox. 4 Oral Aquatic Chronic 2 Eye Dam. 1 Flam. Liq. 2 STOT SE 3
Toxicity	LD50 orally in Rabbit: > 200 - 500 mg/kg less more

Raw materials And Preparation Products

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Material Safety Data Sheet(MSDS)

Questions And Answer

Description
N,N-Diisopropylethylamine is also known as Hunig's base and abbreviated as DIPEA or DIEA, It is a sterically hindered amine and an organic compound. The colourless liquid was named as Hung’s base after Siegfried Hunig, a German chemist. It is noteworthy that the compound is commercially available.
In organic chemistry, N,N-Diisopropylethylamine is used as a base. Since the nitrogen centre is isolated by an ethyl group and the two isopropyl groups, It can bind to protons. The compound is, therefore, a base similar to 2,2,6,6-tetramethylpiperidine, but a poor nucleophile, a blend of properties that makes it valuable as an organic reagent.;
Stability and Reactivity
DIPEA exhibits violent reaction as well as flammability with nitrates, oxidizing agents, and peroxides.
It can also react very exothermically and possibility of spitting with halogens and strong acids. In an alkaline environment, the compound is likely to react violently. In addition, the compound can form toxic products such as n-nitrosamines when combined with nitrous acid as well as oxygen, nitrosating agents, and nitrates.
Under normal conditions (temperature and pressure), DIPEA is very stable. However, it is soluble in most organic solvents. ;
Applications
N,N-Diisopropylethylamine is utilized as a base in the palladium(0)catalysed alkoxycarbonylation of both allyl acetates and phosphates. It is used as a neutralizer of the produced phosphoric acid. Notably, the alkyl ester cannot be produced without DIPEA.
When combined with boryl triflates, N,N-Diisopropylethylamine is used in the enolate synthesis of ketones for application in directed cross-adol reactions.
DIPEA is applied as a proton scavenger in organic synthesis. Since the compound is a sterically hindered amine, it lacks quaternization; therefore, making it a perfect choice of a base for use with extremely reactive alkylating agents. DIPEA is specifically useful as a base in the protection of alcohols as substituted ethers in the field of protecting group chemistry.
In the synthesis of peptides, the compound is also used in the coupling of amino acids. The steric nature and basicity of DIPEA during the coupling reaction affects the degree of racemization.;

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