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Aethylis chloridum
Aethylisaethylis chloridum
Molecular Formula
MDL Number
Molecular Weight
MOL File

Chemical Properties

A highly reactive manmade volatile organic com- pound that is highly reactive in the atmosphere. It readily reacts with oxidizing agents to release the chlorine atoms which, circulate and cause tropo- spheric ozone to decompose.
colourless gas
Ethyl chloride is a colorless gas or liquid (below 12℃) with a pungent, ethereal odor and a burning taste. Shipped as a liquefied compressed gas.
−139 °C(lit.)

12.3 °C(lit.)

0.89 g/mL at 25 °C(lit.)

vapor density 
2.22 (vs air)

vapor pressure 
32.29 psi ( 55 °C)

<−30 °F

storage temp. 
Stable. Highly flammable-may form explosive mixtures with air. Incompatible with strong oxidizing agents, alkali metals and their alloys.
CAS DataBase Reference
75-00-3(CAS DataBase Reference)

Safety Data

Hazard Codes 
Risk Statements 
R45:May cause cancer.
R11:Highly Flammable.
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed .
R36/37/38:Irritating to eyes, respiratory system and skin .
R52/53:Harmful to aquatic organisms, may cause long-term adverse effects in the aquatic environment .
R40:Limited evidence of a carcinogenic effect.
R12:Extremely Flammable.
R39/23/24/25:Toxic: danger of very serious irreversible effects through inhalation, in contact with skin and if swallowed .
R23/24/25:Toxic by inhalation, in contact with skin and if swallowed .
R67:Vapors may cause drowsiness and dizziness.
R66:Repeated exposure may cause skin dryness or cracking.
R22:Harmful if swallowed.
R19:May form explosive peroxides.
Safety Statements 
S9:Keep container in a well-ventilated place .
S16:Keep away from sources of ignition-No smoking .
S33:Take precautionary measures against static discharges .
S36/37:Wear suitable protective clothing and gloves .
S61:Avoid release to the environment. Refer to special instructions safety data sheet .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
S7:Keep container tightly closed .
S29:Do not empty into drains .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S53:Avoid exposure-obtain special instruction before use .
UN 1993 3/PG 2

WGK Germany 


Safety Profile
Suspected carcinogen with experimental carcinogenic and neoplastigenic data. Mildly toxic by inhalation. An irritant to sh, eyes, and mucous membranes. The liquid is harmful to the eyes and can cause some irritation. In the case of guinea pigs, the symptoms attending exposure are similar to those caused by methyl chloride, except that the signs of lung irritation are not as pronounced. It gives some warning of its presence because it is irritating, but it is possible to tolerate exposure to it until one becomes unconscious. It is the least toxic of all the chlorinated hydrocarbons. It can cause narcosis, although the effects are usually transient. A very dangerous fire hazard when exposed to heat or flame; can react vigorously with oxidizing materials. Severe explosion hazard when exposed to flame. Reacts with water or steam to produce toxic and corrosive fumes. Incompatible with potassium. To fight fire, use carbon dioxide. When heated to decomposition it emits toxic fumes of phosgene and Cl-. See also CHLORINATED HYDROCARBONS, ALIPHATIC.

Raw materials And Preparation Products

Hazard Information

General Description
A clear colorless gas with a pungent odor. Flash point-58°F. Boiling point 54°F. Less dense than water and insoluble in water. Vapors are heavier than air. Under prolonged exposure to fire or heat the containers may rupture violently and rocket.
Reactivity Profile
ETHYL CHLORIDE(75-00-3) is heat sensitive. This compound will hydrolyze in the presence of alkalis and water. ETHYL CHLORIDE(75-00-3) reacts with water or steam to produce toxic and corrosive fumes. ETHYL CHLORIDE(75-00-3) can also react vigorously with oxidizing materials. The vapor forms highly flammable mixtures with air. A mixture of this compound with potassium is shock-sensitive. Contact with chemically active metals such as Na, K, Ca, powdered Al, Zn and Mg may result in violent reactions.
Air & Water Reactions
Highly flammable. Insoluble in water.
Highly flammable, severe fire and explosion risk; flammable limits in air 3.8–15.4%. Irritant to eyes. Questionable carcinogen.
Health Hazard
Vapor causes drunkenness, anesthesia, possible lung injury. Liquid may cause frostbite on eyes and skin.
Potential Exposure
Ethyl chloride is used as an ethylating agent in the manufacture of tetraethyl lead, dyes, drugs, and ethyl cellulose; as a pharmaceutical, solvent; alkylating agent; as a refrigerant and as a local anesthetic (freezing).
First aid
If this chemical gets into the eyes, remove any contact lenses at once and irrigate immediately for at least 15 minutes, occasionally lifting upper and lower lids. Seek medical attention immediately. If this chemical contacts the skin, remove contaminated clothing and wash immediately with soap and water. Seek medical attention immediately. If this chemical has been inhaled, remove from exposure, begin rescue breathing (using universal precautions, including resuscitation mask) if breathing has stopped and CPR if heart action has stopped. Transfer promptly to a medical facility. When this chemical has been swallowed, get medical attention. Give large quantities of water and induce vomiting. Do not make an unconscious person vomit
UN1037 Ethyl chloride, Hazard Class: 2.1; Labels: 2.1-Flammable gas. Cylinders must be transported in a secure upright position, in a well-ventilated truck. Protect cylinder and labels from physical damage. The owner of the compressed gas cylinder is the only entity allowed by federal law (49CFR) to transport and refill them. It is a violation of transportation regulations to refill compressed gas cylinders without the express written permission of the owner.
Flammable gas. Slow reaction with water; forms hydrogen chloride gas. Contact with moisture (water, steam) forms hydrochloric acid and/or fumes of hydrogen chloride. May accumulate static electrical charges, and may cause ignition of its vapors. May form explosive mixture with air. Contact with chemically active metals: aluminum, lithium, magnesium, sodium, potassium, zinc may cause fire and explosions. Attacks some plastics and rubber.
Waste Disposal
Return refillable compressed gas cylinders to supplier. Incineration, preferably after mixing with another combustible fuel. Care must be exercised to assure complete combustion to prevent the formation of phosgene. An acid scrubber is necessary to remove the halo acids produced.

Material Safety Data Sheet(MSDS)

msds information

Questions And Answer

Chloroethane (also known as ethyl chloride) is a chemical compound with chemical formula C2H5Cl, and has been widely used in producing tetraethyllead, a gasoline additive. It is a colorless, flammable gas or refrigerated liquid with a faintly sweet odor.
Ethyl chloride is used in the production of ethyl cellulose, use as a solvent, refrigerant, and topical anesthetic, in the manufacture of dyes, chemicals, and pharmaceuticals, and as a medication to alleviate pain associated with insect burns and stings.[1]
In the past, ethyl chloride was used in the production of tetraethyl lead, an anti-knock additive to leaded gasoline. Government-mandated reduction in the amount of lead additives used in gasoline in the United States and a shift to the use of unleaded gasoline has caused a drastic reduction in the amount of ethyl chloride required for the production of tetraethyl lead.[1]
Chemical Properties
Ethyl chloride is a colorless gas with an ethereal odor[1,6]. Ethyl chloride has an odor threshold of 4.2 parts per million (ppm)[7]. Ethyl chloride is slightly soluble in water[1].
The chemical formula for ethyl chloride is C2H5Cl, and it has a molecular weight of 64.52 g/mol[1,3]. The vapor pressure for ethyl chloride is 1,008 mm Hg at 20°C, and the log octanol/water partition; coefficient (log Kow) is 1.43; coefficient (log Kow) is 1.43.[1]
The dominant process for production of ethyl chloride in the USA involves the addition of anhydrous hydrogen chloride to ethylene in the presence of an aluminium chloride catalyst. The hydrochlorination is a liquidphase reaction, carried out at about 40°C. Reacted products are fed into a flash evaporator column, where ethyl chloride is separated from less volatile compounds and then purified by fractionation. Hydrochlorination of ethanol has not been used for US ethyl chloride production since 1980, and chlorination of ethane (catalytically, electrolytically, thermallyor photochemically) has not been used at any production facility in the USA since 1974. Ethyl chloride is also obtained as a by-product from the production of vinyl chloride[1] or chlorofluorocarbon, although this method accounts for only a small amount.
Ethyl chloride is used in the manufacture of tetraethyllead and as an alkylating agent in the production of ethylcellulose (which is used in paper coatings, printing inks, films, adhesives and moulded plastics), ethylhydroxyethylcellulose, and some pharmaceuticals and as a foam-blowing agent in the manufacture of polystyrene. It is used as a local anaesthetic because of its rapid cooling effect as it vaporizes[1]. Historical and minor uses Include use in organic synthesis, as an alkylating agent in the production of aluminium alkyls and other metal alkyls and as a solvent for phosphorus, sulfur, fats, oils, resins and waxes.
Source and exposure
Sources of possible ethyl chloride exposure include the inhalation of contaminated air and ingestion of contaminated drinking water at very low levels. The general population can be exposed to ethyl chloride by skin contact with consumer products that contain ethyl chloride such as solvents and refrigerants. Occupational exposure by inhalation or dermal contact with ethyl chloride can occur in industries such as medical and health services; automotive dealers and service stations; wholesale trade, electric, gas, and sanitary services; machinery (except electrical) and special trade contractors; fabricated metal productions; printing and publishing; painting; rubber and plastic products; and food.[1] Although chemists use tests such as gas chromatography to measure ethyl chloride in blood, milk, or urine, no commonly used medical tests are available to determine whether or not a person has been exposed to ethyl chloride.[1]
Acute Effects
Acute inhalation exposure to high levels of ethyl chloride in humans has resulted in temporary feelings of drunkenness, dizziness, lack of muscle coordination and unconsciousness. Accidental death has resulted from its former medical use as an anesthetic during major surgery.[1,2] Tests involving acute exposure of animals in rats and mice have shown ethyl chloride to have low toxicity from inhalation exposure.[3]
Chronic Effects
Neurological symptoms including ataxia, tremors, speech difficulties, slowed reflexes, involuntary eye movement, and hallucinations, and liver effects were reported in individuals who purposely inhaled very high concentrations of ethyl chloride for a few months.[4]
Some animal studies indicate effects on the lungs, liver, kidneys, and heart due to ethyl chloride exposure via inhalation.[1] The Reference Concentration (RFC) for ethyl chloride is 10 milligrams per cubic meter (mg/m3) based on delayed fetal ossification in mice. The RFC is an estimate (with uncertainty spanning perhaps an order of magnitude) of a continuous inhalation exposure to the human population (including sensitive subgroups), which is likely to be without appreciable risk of deleterious noncancer effects during a lifetime. It is not a direct esimator of risk but rather a reference point to gauge the potential effects. At exposures increasingly greater than the RFC, the potential for adverse health effects increases. Lifetime exposure above the RFC does not imply that an adverse health effect would necessarily occur.[4]
EPA has medium confidence in the study on which the RFC is based because, although the study is well conducted, it does not establish a firm concentration-response relationship with an adverse effect and was not performed at levels eliciting maternal toxicity; medium confidence in the database due to the lack of a multigenerational reproductive study and a developmental study in a second species; and, consequently, medium confidence in the RFC.[4] EPA has not established a Reference Dose (RfD) for ethyl chloride.[4] Reproductive/Developmental Effects
No studies were located regarding reproductive or developmental effects following ethyl chloride inhalation exposure in humans.
Several animal studies found no reproductive effects caused by ethyl chloride exposure. An animal study reported a decrease in uterine weights, while another study reported minimal evidence of fetotoxicity (increase in centers of unossified bones of the skull) from inhalation exposure to ethyl chloride.[1]
Cancer Risk
There are no human cancer data available for ethyl chloride. A 2-year bioassay performed by the NTP indicated that inhaled ethyl chloride is carcinogenic in female mice and may be carcinogenic in rats. Female mice experienced a significant increase in the incidence of uterine tumors and hepatocellular tumors, but the data on male mice were considered inadequate because of a low survival rate. Benign and malignant epithelial neoplasms of the skin, and three uncommon malignant astorcyomas of the brain, were reported in male and female rats, respectively.[5] EPA has not classified ethyl chloride for carcinogenicity.[4]
  1. Agency for Toxic Substances and Disease Registry (ATSDR). Toxicological Profile for Ethyl chloride (Update).Public Health Service, U.S. Department of Health and Human Services, Atlanta, GA. 1998.
  2. U.S. Department of Health and Human Services. Hazardous Substances Data Bank (HSDB, online database). National Toxicology Information Program, National Library of Medicine, Bethesda, MD. 1993.
  3. U.S. Department of Health and Human Services. Registry of Toxic Effects of Chemical Substances (RTECS, online database). National Toxicology Information Program, National Library of Medicine, Bethesda, MD. 1993.
  4. U.S. Environmental Protection Agency. Integrated Risk Information System (IRIS) on Ethyl Chloride. National Center for Environmental Assessment, Office of Research and Development, Washington, DC. 1999.
  5. National Toxicology Program. Toxicology and Carcinogenesis Studies of Ethyl chloride (Ethyl Chloride) (CAS No. 75-00-3) in F344/N Rats and B6C3F1 Mice (Inhalation Studies). TR No. 346. U.S. Department of Health and Human Services, Public Health Service, National Institutes of Health, Bethesda, MD. 1989.
  6. The Merck Index. An Encyclopedia of Chemicals, Drugs, and Biologicals. 11th ed. Ed. S. Budavari. Merck and Co. Inc., Rahway, NJ. 1989.
  7. J.E. Amoore and E. Hautala. Odor as an aid to chemical safety: Odor thresholds compared with threshold limit values and volatilities for 214 industrial chemicals in air and water dilution. Journal of Applied Toxicology, 3(6):272-290. 1983.

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