1-Ethylpiperazine

clear colorless to yellow liquid

1-Ethylpiperazine may be used in the preparation of 2-(2-methoxy-5-((4-methylpiperazin-1-yl)sulfonyl)phenyl)-1H-benzo[d]imidazole hydrochloride and 2-(5-((4-ethylpiperazin-1-yl)sulfonyl)-2-methoxyphenyl)-1H-benzo[d]imidazole hydrochloride.

1-Ethylpiperazine is used in the synthesis of 2-(2-methoxy-5-((4-methylpiperazin-1-yl)sulfonyl)phenyl)-1H-benzo[d]imidazole hydrochloride and 2-(5-((4-ethylpiperazin-1-yl)sulfonyl)-2-methoxyphenyl)-1H-benzo[d]imidazole hydrochloride. It is also employed as an intermediate in veterinary medicine, especially in the production of ciproflmoxacin ethyl. Further, it serves as a precursor to prepare dyes.

The Journal of Organic Chemistry, 22, p. 713, 1957 DOI: 10.1021/jo01357a621

Flammable

Method one is to synthesize piperazine as raw material: piperazine is prepared by reacting with acetonitrile, acetaldehyde or ethyl bromide. The method of synthesizing N-ethyl piperazine by reaction of piperazine and ethyl bromide has the features of simple production process and less by-products, which is a new process with more research in China, but the reaction has the fatal shortcomings of high production cost and low profit margin, which seriously restricts the industrialization of this process, and at the same time, in the process of reaction of piperazine and ethyl bromide, there are inevitably more by-products of N,N-Diethylpiperazine generation. The second method is to synthesize with ethylamine as raw material: ethylamine and ethylene oxide are prepared by addition and cyclization. The disadvantages of this method are high reaction temperature, resulting in high equipment requirements; more reaction steps, more equipment instrumentation, resulting in process control, three waste disposal difficulties; poor catalyst selectivity, low conversion rate, more by-products.