67832-11-5

white to light yellow crystal powder

4-Bromo-2-methylbenzonitrile serves as a precursor for synthesizing 1,3,5-tris(4-bromo-2-methylphenyl)triazine under acid-catalyzed conditions with triflic acid[1]. The compound is reduced using borane–tetrahydrofuran complex to yield 4-bromo-2-methylbenzylamine[2].

[1] Barbee, D., Barron, A. R. (2019). Scalable synthesis of multi-substituted aryl-phosphonates: Exploring the limits of isoretical expansion and the synthesis of new triazene-based phosphonates. Phosphorus, Sulfur, and Silicon and the Related Elements, 195(3), 231–244. https://doi.org/10.1080/10426507.2019.1673750
[2] Huang, J., Ma, Z., Peng, X., Yang, Z., Wu, Y., Zhong, G., Ouyang, T., Chen, Z., Liu, Y., Wang, Q., Chen, J., Chen, T., Zeng, Z. (2024). Discovery of Novel Potent and Fast BTK PROTACs for the Treatment of Osteoclasts-Related Inflammatory Diseases. Journal of Medicinal Chemistry, 67(4), 2438–2465. https://doi.org/10.1021/acs.jmedchem.3c01414