ChemicalBook CAS DataBase List 122453-73-0

122453-73-0

Name	Chlorfenapyr
CAS	122453-73-0
Molecular Formula	C15H11BrClF3N2O
MDL Number	MFCD01631152
Molecular Weight	407.61
MOL File	122453-73-0.mol

Synonyms

4-BROMO-2-(4-CHLOROPHENYL)-1-(ETHOXYMETHYL)-5-(TRIFLUOROMETHYL)-1H-PYRROL-3-CARBONITRILE CHLORFENAPYR PIRATE STALKER 4-bromo-2-(4-chlorophenyl)-1-ethoxymethyl-5-trifluoromethyl-1H-pyrrole-3-carbonitrile 4-bromo-2-(4-chlorophenyl)-1-ethoxymethyl-5-trifluoromethylpyrrole-3-carbonitrile Alert Citrex Intrepid Sunfire AC 303630 1H-Pyrrole-3-carbonitrile, 4-bromo-2-(4-chlorophenyl)-1-(ethoxymethyl)-5-(trifluoromethyl)- chlorfenapyr (bsi, pa iso) chlorfenapyr 4-bromo-2-(4-chlorophenyl)-1-ethoxymethyl-5-trifluoromethylpyrrole-3-carbonitrile CL 303630 Kotersu Kotetsu Pylon

Chemical Properties

Melting point	91-92°
Boiling point	443.5±45.0 °C(Predicted)
density	1.53±0.1 g/cm3(Predicted)
storage temp.	0-6°C
solubility	DMSO: 250 mg/mL (613.33 mM)
Water Solubility	Insoluble in water
form	neat
pka	-18.00±0.70(Predicted)
color	White to Almost white
BRN	6940152
Henry's Law Constant	1.7×10³ mol/(m³Pa) at 25℃, HSDB (2015)
Major Application	agriculture environmental
InChI	InChI=1S/C15H11BrClF3N2O/c1-2-23-8-22-13(9-3-5-10(17)6-4-9)11(7-21)12(16)14(22)15(18,19)20/h3-6H,2,8H2,1H3
InChIKey	CWFOCCVIPCEQCK-UHFFFAOYSA-N
SMILES	N1(COCC)C(C(F)(F)F)=C(Br)C(C#N)=C1C1=CC=C(Cl)C=C1
CAS DataBase Reference	122453-73-0(CAS DataBase Reference)
NIST Chemistry Reference	Chlorfenapyr(122453-73-0)
EPA Substance Registry System	122453-73-0(EPA Substance)

Safety Data

Symbol(GHS)	GHS06,GHS09
Signal word	Danger
Hazard statements	H302-H331-H410
Precautionary statements	P261-P264-P270-P273-P301+P312-P304+P340+P311
Hazard Codes	T;N,N,T
Risk Statements	R22:Harmful if swallowed. R23:Toxic by inhalation. R50/53:Very Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment . less more
Safety Statements	S13:Keep away from food, drink and animal feeding stuffs . S36/37:Wear suitable protective clothing and gloves . S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) . S60:This material and/or its container must be disposed of as hazardous waste . S61:Avoid release to the environment. Refer to special instructions safety data sheet . less more
RIDADR	UN 2811
WGK Germany	3
HS Code	2933.99.1701
Storage Class	6.1C - Combustible acute toxic Cat.3 toxic compounds or compounds which causing chronic effects
Hazard Classifications	Acute Tox. 3 Inhalation Acute Tox. 4 Oral Aquatic Acute 1 Aquatic Chronic 1
Hazardous Substances Data	122453-73-0(Hazardous Substances Data)
Toxicity	LD50 (single dose) in male, female rats (mg/kg): 223, 459 orally; in rabbits: >2000 dermally (Lovell); LC50 in Japanese carp: 0.5 ppm (Lovell) less more

Raw materials And Preparation Products

Hazard Information

Hazard

A poison by ingestion. Moderately toxic by inhalation.

Chemical Properties

Off-White Solid

Uses

Chlorfenapyr is a halogenated pyrrole based pro-insecticide. Chlorfenapyr functions by metabolizing into an active insecticide after entering the host. Chlorfenapyr is used primarily as a means of pes t control on cotton.

Uses

Insecticide. Acaricide.

Definition

ChEBI: Chlorfenapyr is a member of the class of pyrroles that is 4-bromo-1H-pyrrole-3-carbonitrile which is substituted at positions 1, 2 and 5 by ethoxymethyl, p-chlorophenyl and trifluoromethyl groups, respectively. A proinsecticide used for termite control and crop protection against several insects and mite pests. It has a role as a proinsecticide and a proacaricide. It is an organofluorine acaricide, an organochlorine acaricide, an organochlorine insecticide, an organofluorine insecticide, a member of monochlorobenzenes, a nitrile, a member of pyrroles and a hemiaminal ether. It is functionally related to a tralopyril.

Production Methods

Chlorfenapyr is produced commercially through a multi-step synthesis that centres on the creation of its key intermediate: 2-(4-chlorophenyl)-1-methyl-5-(trifluoromethyl)-1H-pyrrole-3-carbonitrile. This compound is synthesised via a series of reactions involving halogenated aromatic precursors and pyrrole derivatives. Once the intermediate is obtained, it undergoes etherification with ethyl chloroacetate to form the final active ingredient, 4-bromo-2-(4-chlorophenyl)-1-(ethoxymethyl)-5-(trifluoromethyl)-1H-pyrrole-3-carbonitrile.

Agricultural Uses

Acaracide, Insecticide, Miticide: Severely Restricted for use in EU. Active in U.S. as a foliar spray in greenhouses for ornamental crops and target pests including mites, caterpillar pests, thrips, and fungus gnats. No food use in U.S. Used on ornamental crops in commercial greenhouses to control mites, caterpillar pests, thrips and fungus gnats. Not for food use. Not an approved substance in EU countries. Registered for use in the U.S.

Trade name

AC 303630®; CL 303630®; PHANTOM®; PIRATE® 3 F; PYLON®; SUMILARV® chlorfenapyr Chemical class: Pyrrole (Pyrazole); Organofluorine

Mechanism of action

Limited systemic activity, mainly stomach but some contact action. Uncoupler of oxidative phosphorylation.

References

[1] BLACK B.C. Insecticidal Action and Mitochondrial Uncoupling Activity of AC-303,630 and Related Halogenated Pyrroles[J]. Pesticide Biochemistry and Physiology, 1994, 50 2: Pages 115-128. DOI: 10.1006/pest.1994.1064
[2] C. SHEPPARD J A J. Increased Susceptibility of Pyrethroid-Resistant Horn Flies (Diptera: Muscidae) to Chlorfenapyr[J]. Journal of Economic Entomology, 1998, 91 1: 398-400. DOI: 10.1093/jee/91.2.398
[3] KAMARAJU RAGHAVENDRA. Chlorfenapyr: a new insecticide with novel mode of action can control pyrethroid resistant malaria vectors.[J]. ACS Applied Bio Materials, 2011: 16. DOI: 10.1186/1475-2875-10-16

Pesticide Type

Insecticide; Acaricide; Miticide

Material Safety Data Sheet(MSDS)

Questions And Answer

Spectrum Detail

Well-known Reagent Company Product Information

Supplier

Jiangsu Ruidian Pharmaceutical Co., Ltd

Telephone 15896106238

Website

Qingdao Baiyi Chemical Co., Ltd

Telephone13953303907

Websitehttp://www.baiyihuaxue.com/Index.htm

Henan Yanyuan Biotechnology Co., Ltd

Telephone 18637186683

Websitehttp://www.yanyuansw.com/

Shandong Yeyang Chemical Co., Ltd.

Telephone 15692312955

Website

Huaibei Longxi Biotechnology Co., Ltd.

Telephone 18956118929

Websitehttps://www.chemicalbook.com/supplier/25296122/1.htm

J & K SCIENTIFIC LTD.

Telephone18210857532 18210857532

Websitehttps://www.jkchemical.com

Capot Chemical Co., Ltd

Telephone+86 (0) 571 85 58 67 18

Websitehttp://www.capotchem.com/

Beijing Ouhe Technology Co., Ltd

Telephone13552068683 13522913783

Websitehttp://www.ouhetech.cn/

Chemsky（shanghai）International Co.,Ltd.

Telephone021-50135380

Websitehttp://www.shchemsky.com

Sichuan Kulinan Technology Co., Ltd

Telephone400-1166-196 18981987031

Websitehttp://www.hx-r.com/

Shanghai T&W Pharmaceutical Co., Ltd.

Telephone+86 21 61551611

Websitehttp://www.trustwe.com

Guangzhou Isun Pharmaceutical Co., Ltd

Telephone020-39119399 18927568969

Websitehttp://www.isunpharm.com

Nanjing Sunlida Biological Technology Co., Ltd.

Telephone025-57798810 18652991625

Website

TargetMol Chemicals Inc.

Telephone021-021-33632979 15002134094

Websitehttps://www.targetmol.cn/

Shanghai JONLN Reagent Co., Ltd.

Telephone400-0066400 13621662912

Websitehttp://www.jonln.com

TianJin Alta Scientific Co., Ltd.

Telephone022-65378550-8551

Websitehttp://www.altascientific.cn

Quality Control Solutions Ltd.

Telephone0755-66853366 13670046396

Websitehttp://www.qcsrm.com

Finetech Industry Limited

Telephone027-87465837 19945049750

Websitehttps://www.finetechchem.com/

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122453-73-0

Chemical Properties

Safety Data

Raw materials And Preparation Products

Raw materials

Hazard Information

Hazard

Chemical Properties

Uses

Uses

Definition

Production Methods

Agricultural Uses

Trade name

Mechanism of action

References

Pesticide Type

Material Safety Data Sheet(MSDS)

Questions And Answer

Description

Reference

Spectrum Detail

Well-known Reagent Company Product Information

Supplier

Related Products