Chemical Properties
White or almost white, crystalline powder.
Originator
Sterane, Phipharmex ,US ,1955
Uses
Synthetic corticosteroid; metabolically interconvertible with prednisone.
Definition
ChEBI: Prednisolone acetate is a corticosteroid hormone.
Manufacturing Process
To a solution of 0.85 gram of 1,4-pregnadiene-11β,17α,21-triol-3,20-dione (prednisolone) in 5 ml of pyridine are added 3 ml of acetic anhydride. The reaction mixture is allowed to stand at room temperature overnight and is then diluted with ice water. The resulting precipitate is filtered from the mixture and recrystallized from acetone-hexane. There is recovered 0.45 gram of 1,4-pregnadiene-11β,17α,21-triol-3,20-dione 21-acetate, MP 235°239°C. On recrystallization, the MP rose to 237°-239°C.
Brand name
Econopred (Alcon); Meticortelone (Schering); Omnipred (Alcon); Sterane (Pfizer).
Therapeutic Function
Glucocorticoid
Biological Activity
Prednisolone Acetate (Omnipred) is a synthetic corticosteroid that is a particularly potent immunosuppressant.
Clinical Use
For rheumatoid arthritis, rheumatic fever, lupus erythematosus, scleroderma, dermatomyositis, acute lymphoblastic leukemia, etc.
Purification Methods
Recrystallise prednisolone acetate from EtOH, Me2CO, Me2CO/hexane, and it has UV with max at 243nm in EtOH. [Joly et al. Bull Soc Chim Fr 366 1958; Herzog et al. J Am Chem Soc 77 4781 1955, Beilstein 8 IV 3468.]
References
[1] Patent: CN105503986, 2016, A. Location in patent: Paragraph 0027; 0028
