51012-33-0

White Solid

Tiapridal,Delagrange,France,1977

Dopamine antagonist;Antidyskinetic

Tiapride hydrochloride is a D2 and D3 dopamine receptor antagonist and a antipsychotic drug predominately used in the pharmacotherapy of patients with dementia.

ChEBI:Tiapride hydrochloride is a member of benzamides.

5 g of 2-methoxy-5-methylsulfonylbenzoic acid, 50 ml of dioxan, 3.02 ml of triethylamine and 3 g of isobutyl chloroformate were introduced into a 250 ml balloon flask at ambient temperature.
After the mixture had been stirred for 30 minutes, 3 g of N,N_x0002_diethylethylenediamine were added. The reaction mixture was stirred for 6 hours and the solvents were evaporated under vacuum.
The residue was dissolved in 50 ml of water and the solution was made alkaline with sodium hydroxide. The precipitate formed was filtered, washed and dried in a drying oven at 60°C. 6 g of N-(diethylaminoethyl)-2-methoxy- 5-methylsulfonylbenzamide (melting point: 124°C to 125°C) was produced.

Antiemetic

Store at -20°C, protect from light