34316-15-9

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• Description

  Chelerythrine chloride is the chloride form of Chelerythrine chloride which is a benzophenanthridine alkaloid isolated from the plant Chelidonium majus (greater celandine). It is a kind of potent, selective, and cell-permeable protein kinase C inhibitor, an efficient antagonist of G-protein-coupled CB1 receptors, and an independent activator of MAPK pathways. It has a wide range of biological activities including antiplatelet, anti-inflammatory, antibacterial and antitumor effects. It has reported of that it is capable of inducing apoptosis in HL-60 human promyelocytic leukemia cells and several other cancer cell lines. The underlying mechanism is through its effects of inhibiting the binding of BclXL to Bax or Bad. ;

• References

  https://en.wikipedia.org/wiki/Chelerythrine
  https://www.scbt.com/scbt/product/chelerythrine-chloride-3895-92-9
  https://www.tocris.com/dispprod.php?ItemId=2342#.WQmZVVNsgZQ ;

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