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The general procedure for the synthesis of 2-(1-methyl-1H-benzo[d]imidazol-2-yl)acetonitrile from 2-cyanomethylbenzimidazole and dimethyl sulfate was as follows: 1.2 equivalents of dimethyl sulfate was added drop-wise to a mixture containing benzimidazol-2-ylacetonitrile (3b) and 1.1 equivalents of aqueous sodium hydroxide, and the temperature of the reaction was maintained at 30 °C, with continuous stirring for 1 hour. After completion of the reaction, the mixture was cooled to room temperature and the precipitate was collected by filtration, washed several times with deionized water and subsequently dried. The yield of the final product was 78%.

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