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21898-19-1

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Identification

Name
Clenbuterol hydrochloride
CAS
21898-19-1
Synonyms
4-AMINO-ALPHA-(T-BUTYLAMINOMETHYL)3,5-DICHLOROBENZYL ALCOHOL HCL
4-AMINO-ALPHA-[T-BUTYLAMINOMETHYL]-3,5-DICHLOROBENZYL ALCOHOL HYDROCHLORIDE
CLENBUTEROL HCL
CLENBUTEROL HYDROCHLORIDE
NAB 365CL
4-amino-alpha-((tert-butylamino)methyl)-3,5-dichlorobenzylalcoholhydrochlor
4-amino-alpha-((tert-butylamino)methyl)-3,5-dichloro-benzylalcohomonohydr
4-amino-alpha-((tert-butylamino)methyl)-3,5-dichlorobenzylalkohol-hydrochlor
clenbuterolclorhidrato
nab365
planiparthydrochloride
spiropent
ventipulmin
4-Amino-α-(t-butylaminomethyl)-3,5-dichlorobenzyl alcohol hydrochloride
Clenbuterol Hhydrochloride
Ventipulmi
Benzenemethanol, 4-amino-3,5-dichloro-.alpha.-(1,1-dimethylethyl)aminomethyl-, monohydrochloride
clenbutreol hydrochloride
1-(4-Amino-3,5-dichlorophenyl)-2-(tert-butylamino)ethanol hydrochloride
4-Amino-α-(tert-butylaminomethyl)-3,5-dichlorobenzyl alcohol monohydrochloride
EINECS(EC#)
244-643-7
Molecular Formula
C12H19Cl3N2O
MDL Number
MFCD00083280
Molecular Weight
313.65
MOL File
21898-19-1.mol

Chemical Properties

Appearance
Colourless Microcyrstalline Powder
Melting point 
174-175.5°C
mp 
174-175.5°C
Fp 
9℃
storage temp. 
2-8°C

solubility 
Soluble in water and in ethanol (96 per cent), slightly soluble in acetone.
form 
neat
Usage
Substituted phenylethanolamine with 2 sympathomimetic activity. Bronchodilator
Merck 
14,2347
InChIKey
OPXKTCUYRHXSBK-UHFFFAOYSA-N
CAS DataBase Reference
21898-19-1(CAS DataBase Reference)

Safety Data

Hazard Codes 
T
Risk Statements 
R25:Toxic if swallowed.
Safety Statements 
S22:Do not breathe dust .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
RIDADR 
UN 2811 6.1/PG 3

WGK Germany 
3

RTECS 
DN3180000

HazardClass 
6.1(b)
PackingGroup 
III
HS Code 
29221990
Toxicity
LD50 in mice, rats, guinea pigs (mg/kg): 176, 315, 67.1 orally; 27.6, 35.3, 12.6 i.v. (Ueberberg)

Hazard Information

Chemical Properties
Colourless Microcyrstalline Powder
Definition
Clenbuterol hydrochloride is a hydrochloride that is the monohydrochloride salt of clenbuterol.
Veterinary Drugs and Treatments
Clenbuterol is approved for use in horses as a bronchodilator in the management of airway obstruction, such as recurrent airway obstruction (RAO; formerly COPD).
It has been used as a partitioning agent in food producing animals, but its use for this purpose is banned in the USA as relay toxicity in humans has been documented.

Questions And Answer

Selective β2 adrenergic receptor agonist
Clenbuterol-hydrochloride exhibits as white crystalline powder. Its chemical name is hydroxymethyl tert-butanol adrenaline or 2-[(tert-butylamino) methyl]-4-amino-3, 5-dichlorobenzene methoxide salt. It is a kind of potent, selectively β2 adrenergic receptor agonists and can be used for relaxing bronchial smooth muscle for the treatment of bronchial asthma, asthmatic bronchitis and bronchitis with emphysema.
The main component of "Shouroujing" is clenbuterol. Because of its certain effects on animals such as promoting the protein synthesis of muscle, promoting lipid decomposition and reducing fat accumulation, it can cause the relative increase of lean meat content of the animal and thus improving livestock quality. Owing to this property, we also referred it as "growth promoters" and "nutrition re-dispersing agent."
In the early 1960s, it was found that it can promote the animal growth; In the 1970s, the United States had introduced it into poultry production and it has become the world's most widely used β-stimulants. However, as the substance has a strong thermal stability and biochemical stability, after animal consumption, it is capable of forming residue in organs and tissues. Upon eating pork containing clenbuterol, people can get poisoning symptoms. Thus, many countries in the world had sooner or later banned the application of β-agonists in animal husbandry. Many countries have developed detection method for monitoring β-agonists residues and clenbuterol of the feed. In 1997, our government had also banned clenbuterol for being used as feed additives.
Precautions: a minority of patients may get adverse reactions such as mild heart palpitations, tremor, and dizziness with the symptoms gradually disappear in general after the medication. Patients of hyperthyroidism, tachycardia or hypertension should be taken with caution.
Preparation: ordinary tablets, aerosols, suppositories, films agent and patches.
The above information is edited by the Chemicalbook of Dai Xiongfeng
The above information is edited by the Chemicalbook of Dai Xiongfeng.
Uses
Clenbuterol hydrochloride can be used for the prevention and treatment of bronchial asthma, chronic bronchitis, emphysema-accompanied bronchial spasms caused by bronchitis.Clenbuterol hydrochloride is a kind of β2-adrenergic receptor agonists and can be used as bronchodilators.
Category toxic
substances
Toxicity grading
highly toxic
Acute toxicity
intraperitoneal-mouse TDL0: 2 mg/kg
Flammability and hazard characteristics
flammable with combustion cause its decomposition into toxic chloride and nitrogen oxide gases
Storage properties, warehouse
cold, ventilated and dry; store it separately from food raw materials
Extinguishing media
Water, carbon dioxide, dry, sandy soil.

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