Synthesis
General procedure for the synthesis of 2-methyl-4-amino-6-chloropyrimidine from 4,6-dichloro-2-methylpyrimidine: 4,6-dichloro-2-methylpyrimidine (50 g, 0.31 mol) and a methanol solution of ammonia (0.5 L) were added to a 1 L triple-necked flask, and the reaction was stirred for 5 h at 50 °C. After completion of the reaction, the reaction mixture was cooled to 0 °C. Subsequently, filtration was carried out at room temperature and the filter cake was washed with petroleum ether (100 ml). Finally, the product was dried under reduced pressure to afford 2-methyl-4-amino-6-chloropyrimidine (40.9 g, yield: 92%) as a white solid.
References
[1] Patent: CN106478519, 2017, A. Location in patent: Paragraph 0024-0027; 0033-0035; 0041-0044; 0053-0056
[2] Journal of Organic Chemistry, 2016, vol. 81, # 9, p. 3780 - 3789
[3] Tetrahedron Letters, 2009, vol. 50, # 41, p. 5729 - 5732
[4] Patent: US2015/133474, 2015, A1. Location in patent: Paragraph 0023-0024
[5] Patent: WO2015/73281, 2015, A1. Location in patent: Page/Page column 6
