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121-44-8

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Identification

Name
Triethylamine
CAS
121-44-8
Synonyms
AKOS BBS-00004381
N,N-DIETHYLETHANAMINE
TEA
TETN
TRIETHYLAMINE
(C2H5)3N
(Diethylamino)ethane
ai3-15425
Ethanamine, N,N-diethyl-
ethanamine,n,n-diethyl-
N,N,N-Triethylamine
N,N-Diethylethanamin
n,n-diethyl-ethanamin
TEN
Triaethylamin
Triethylamin
Trietilamina
Diethylethanamine
Triethylamine, Free Base (1.08217)
Trethylamine
EINECS(EC#)
204-469-4
Molecular Formula
C6H15N
MDL Number
MFCD00009051
Molecular Weight
101.19
MOL File
121-44-8.mol

Chemical Properties

Appearance
Clear colorless liquid
Appearance
Triethylamine is a colorless liquid. Strong ammonia odor.
mp 
-115 °C
bp 
90 °C
density 
0.728
vapor density 
3.5 (vs air)

vapor pressure 
51.75 mm Hg ( 20 °C)

FEMA 
4246
refractive index 
n20/D 1.401(lit.)

Fp 
20 °F

storage temp. 
2-8°C

Stability:
Stable. Extremely flammable. Readily forms explosive mixtures with air. Note low flash point. Incompatible with strong oxidizing agents, strong acids, ketones, aldehydes, halogenated hydrocarbons.
Water Solubility 
133 g/L (20 ºC)
Merck 
14,9666
BRN 
1843166
Uses
Catalytic solvent in chemical synthesis; accelerator activators for rubber; wetting, penetrating, and waterproofing agents of quaternary ammonium types; curing and hardening of polymers (e.g., corebinding resins); corrosion inhibitor; propellant.
CAS DataBase Reference
121-44-8(CAS DataBase Reference)
NIST Chemistry Reference
Triethylamine(121-44-8)
EPA Substance Registry System
121-44-8(EPA Substance)

Safety Data

Hazard Codes 
F,C
Risk Statements 
R11:Highly Flammable.
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed .
R35:Causes severe burns.
Safety Statements 
S3:Keep in a cool place .
S16:Keep away from sources of ignition-No smoking .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S29:Do not empty into drains .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
RIDADR 
UN 1296 3/PG 2

WGK Germany 
1

RTECS 
YE0175000


34
Hazard Note 
Highly Flammable/Corrosive
HazardClass 
3
PackingGroup 
II
HS Code 
29211910
Safety Profile
Moderately toxic by ingestion and skin contact. Mildly toxic by inhalation. Human systemic effects: visual field changes. Experimental reproductive effects. Mutation data reported. A skin and severe eye irritant. Can cause kidney and liver damage. A very dangerous fire hazard when exposed to heat, flame, or oxidizers. Explosive in the form of vapor when exposed to heat or flame. Complex with dinitrogen tetraoxide explodes below 0°C when undduted with solvent. Exothermic reaction with maleic anhydride above 150°C. Can react with oxidzing materials. Incompatible with N2O4. To fight fire, use CO2, dry chemical, alcohol foam. When heated to decomposition it emits toxic fumes of NOx.
Hazardous Substances Data
121-44-8(Hazardous Substances Data)

Raw materials And Preparation Products

Raw materials
Etanol-->Ammonia-->Hydrogen-->Diethylamine-->Triethanolamine-->KAOLIN
Preparation Products
4-Cyanophenyl isocyanate-->TRI-TERT-BUTYL 1 4 7 10-TETRAAZACYCLODOD-->ETHYL 2-PHENYL-3-(TRIFLUOROMETHYL)PYRAZOLE-4-CARBOXYLATE-->2-CYANO-4-PYRIDINE CARBOXYLIC ACID-->Camostat-->fluorocarbon sulfactant 6201-->Methyl trans-2-nonenoate-->polyurethane water-based emulsion finishes PU-II series-->6-FLUORO-4-HYDROXY-2-(TRIFLUOROMETHYL)QUINOLINE-->Methyl 2-aminothiophene-3-carboxylate-->DI-2-PYRIDYL THIONOCARBONATE-->2-Thienyl isocyanate-->3-Cyanophenyl isocyanate-->4-(BOC-AMINOMETHYL)PYRIDINE-->5-Chloro-2-(methylthio)pyrimidine-4-carboxylic acid-->METHYL 3-[(2-BROMOACETYL)AMINO]THIOPHENE-2-CARBOXYLATE-->2-Chlorophenyl isocyanate-->3-[(N-(TERT-BUTYLOXYCARBONYL)AMINO)METHYL]PYRIDINE-->2-Methoxyphenyl isocyanate-->(R)-Glycidyl butyrate-->4-Fluorophenyl isocyanate-->Triisopropyl phosphite-->N-Boc-N,N-bis(2-chloroethyl)amine-->5-TERT-BUTOXYCARBONYLAMINO-PYRIDINE-3-CARBOXYLIC ACID-->2-FLUOROPHENYL ISOCYANATE-->4-Methoxyphenyl isocyanate-->Metazachlor-->indomethacin farnesil-->2-amino-5-chloro-diphenyl methanol-->S-2-Benzothiazolyl 2-amino-alpha-(methoxyimino)-4-thiazolethiolacetate-->3-FLUOROPHENYL ISOCYANATE-->3,4-(METHYLENEDIOXY)PHENYL ISOCYANATE-->Ampicillin-->1-(4-NITROBENZENESULFONYL)-1H-1,2,4-TRIAZOLE-->3-Hydroxy-6-methyl-2-pyridinemethanol-->Tetraethylammonium bromide-->Pyridat-->N,N-Diethylhydroxylamine-->Dichlormid-->2-Mercaptobenzothiazolyl-(Z)-(2-aminothiazol-4-yl)-2-(tert-butoxycarbonyl) isopropoxyiminoacetate

Hazard Information

General Description
A clear colorless liquid with a strong ammonia to fish-like odor. Flash point 20°F. Vapors irritate the eyes and mucous membranes. Less dense (6.1 lb/gal) than water. Vapors heavier than air. Produces toxic oxides of nitrogen when burned.
Reactivity Profile
TRIETHYLAMINE(121-44-8) reacts violently with oxidizing agents. Reacts with Al and Zn. Neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen may be generated in combination with strong reducing agents, such as hydrides.
Air & Water Reactions
Highly flammable. Soluble in water.
Health Hazard
Vapors irritate nose, throat, and lungs, causing coughing, choking, and difficult breathing. Contact with eyes causes severe burns. Clothing wet with chemical causes skin burns.
Potential Exposure
Triethylamine is and aliphatic amine used as a solvent; corrosion inhibitor; in chemical synthesis; and accelerator activators; paint remover; base in methylene chloride or other chlorinated solvents. TEA is used to solubilize 2,4,5-T in water and serves as a selective extractant in the purification of antibiotics. It is used to manufacture quaternary ammonia compounds and octadecyloxymethyltriethylammonium chloride; an agent used in textile treatment.
Fire Hazard
Flammable/combustible material. May be ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water.
First aid
If this chemical gets into the eyes, remove any contact lenses at once and irrigate immediately for at least 15 minutes, occasionally lifting upper and lower lids. Seek medical attention immediately. If this chemical contacts the skin, remove contaminated clothing and wash immediately with soap and water. Seek medical attention immediately. If this chemical has been inhaled, remove from exposure, begin rescue breathing (using universal precautions, including resuscitation mask) if breathing has stopped and CPR if heart action has stopped. Transfer promptly to a medical facility. When this chemical has been swallowed, get medical attention. If victim is conscious, administer water, or milk. Do not induce vomiting. Give large quantities of water and induce vomiting. Do not make an unconscious person vomit. Medical observation is recommended for 24-48 hours after breathing overexposure, as pulmonary edema may be delayed. As first aid for pulmonary edema, a doctor or authorized paramedic may consider administering a drug or other inhalation therapy.
Shipping
UN1296 Triethylamine, Hazard Class: 3; Labels: 3-Flammable liquid, 8-Corrosive material.
Incompatibilities
A strong base. Violent reaction with strong acids; halogenated compounds; and strong oxidizers. Attacks some forms of plastics, rubber and coatings. Corrosive to aluminum, zinc, copper, and their alloys in the presence of moisture. Reaction with nitrosating agents (e.g., nitrites, nitrous gases, and nitrous acid) capable of releasing carcinogenic nitrosamines.
Waste Disposal
Controlled incineration (incinerator equipped with a scrubber or thermal unit to reduce nitrogen oxides emissions).

Material Safety Data Sheet(MSDS)

Questions And Answer

Outline
Triethylamine (formula: C6H15N), also known as N, N-diethylethanamine, is the most simple tri-substituted uniformly tertiary amine, having typical properties of tertiary amines, including salifying, oxidation, Hing Myers test (Hisberg reaction) for triethylamine does not respond. It is colorless to pale yellow transparent liquid, with a strong smell of ammonia, slightly fuming in the air. Boiling point: 89.5 ℃, relative density (water = 1): 0.70, the relative density (Air = 1): 3.48, slightly soluble in water, soluble in alcohol, ether. Aqueous solution is alkaline, flammable. Vapor and air can form explosive mixtures, the explosion limit is 1.2% to 8.0%. It is toxic, with a strong irritant.
Uses
Triethylamine is a clear, colorless liquid with an Ammonia or fish-like odor. It is used in making waterproofing agents, and as a catalyst, corrosion inhibitor and propellant.
It is mainly used as base, catalyst, solvent and raw material in organic synthesis and is generally abbreviated as Et3N, NEt3 or TEA. It can be used to prepare phosgene polycarbonate catalyst, polymerization inhibitor of tetrafluoroethylene, rubber vulcanization accelerator, special solvent in paint remover, enamel anti-hardener, surfactant, antiseptic, wetting agent, bactericides, ion exchange resins, dyes, fragrances, pharmaceuticals, high-energy fuels, and liquid rocket propellants, as a curing and hardening agent for polymers and for the desalination of seawater.
Consumption Quota of in medical industry:
Medicine
Consumption Quota(Unit: t/t)
Ampicillin sodium
0.465
Amoxicillin
0.391
Cefazolin sodium
2.442
Cefazolin organism
1.093
Oxygen piperazine penicillin
0.584
Ketoconazole
8.00
Vitamin B6
0.502
Fluorine organism acid
10.00
Praziquantel
0.667
Thiotepa
1.970
Penicillamine
1.290
Berberine hydrochloride
0.030
Verapamil
0.540
Alprazolam
3.950
Adjacent benzene acetic acid
0.010

Production
It is produced by ethanol and ammonia in the presence of hydrogen, in containing Cu-Ni-clay catalyst reactor under heating conditions (190 ± 2 ℃ and 165 ± 2 ℃) reaction. The reaction also produces ethylamine and diethylamine, products were condensed and then absorption by ethanol spray to obtain crude triethylamine, through the final separation, dehydration and fractionation, pure triethylamine is obtained.
Reaction
  • It can be used to reduce the alkali in the reaction.

  • Alkylation reaction
  • Oxidation reaction

Health Effects
Triethylamine can affect you when inhaled and by passing through the skin.
  1. Contact can severely irritate and bum the skin and eyes with possible eye damage.
  2. Exposure can irritate the eyes, nose and throat.
  3. Inhaling Triethylamine can irritate the lungs. Higher exposures may cause a build-up of fluid in the lungs (pulmonary edema), a medical mergency.
  4. Triethylamine may cause a skin allergy.
  5. Triethylamine may affect the liver and kidneys.
  6. Triethylamine is a flammable liquid and a dangerous fire hazard.

Category
Flammable liquids
Toxicity grading
Toxic
Acute toxicity
Oral-rat LD50: 460 mg/kg; Oral-Mouse LD50: 546 mg/kg
Stimulus data
Eyes-rabbit 250 mg severe
Explosive hazardous characteristics
Mixed with air can be explosive
Flammability hazard characteristics
In case of fire, high temperature, oxidant, it is flammable, combustion produces toxic fumes of nitrogen oxides
Storage Characteristics
Treasury ventilation low-temperature drying, stored separately from oxidants, acids
Extinguishing agent
Dry, dry sand, carbon dioxide, foam
Occupational standards
TWA 40 mg/cubic meter

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