14396-65-7

110-14-5

14396-65-7

General procedure for the synthesis of 1,4-dibromo-2,3-butanediol from succinamide: 2 moles of 1,4-diaminobutanedione and 6 moles of 2-pyrrolidinone were added to the reaction vessel and the temperature of the reaction system was lowered to 7 °C. Subsequently, 3 moles of bismuth basic carbonate catalyst and 6 moles of hydrogen were added. A bromide solution with a mass fraction of 20% was slowly added to the reaction system. After maintaining the reaction for 60 minutes, the temperature of the system was continued to be lowered to 3 °C and the stirring speed was controlled to 190 rpm and this condition was maintained for 60 minutes. Upon completion of the reaction, it was allowed to stand for 50 minutes to precipitate the solid product. After filtration, the filtrate was washed sequentially with 66% by mass of methyl butyrate solution and 83% by mass of octanenitrile solution. Finally, the crystalline product was precipitated by recrystallization with 96% mass fraction cyclohexanone solution. Dehydration was carried out by anhydrous potassium carbonate as dehydrating agent, and finally 471.2 g of 1,4-dibromo-2,3-butanediol was obtained as a finished product with a yield of 95%.