106-94-5

A colorless liquid. Slightly denser than water and slightly soluble in water. Flash point below 75°F. When heated to high temperatures may emit toxic fumes.

Halogenated aliphatic compounds, such as 2-BROMOPROPANE, are moderately or very reactive. Reactivity generally decreases with increased degree of substitution of halogen for hydrogen atoms. Low molecular weight haloalkanes are highly flammable and can react with some metals to form dangerous products. Materials in this group are incompatible with strong oxidizing and reducing agents. Also, they are incompatible with many amines, nitrides, azo/diazo compounds, alkali metals, and epoxides. Emits toxic fumes of bromine when burned.

Highly flammable. Slightly soluble in water.

A flammable liquid.

Irritating to the eyes, nose, throat, upper respiratory tract, and skin.

Bromopropane is a toxic and highly flammable, colorless liquid; Flash point # 22℃. Molecularweight=123.0 (1-bromopropane); 123.0 (2-bromopropane); Boiling point=71℃ (1-bromopropane); 59.4℃(2-bromopropane); Freezing/Melting point=-110℃ (1-bromopropane); - 89℃ (2-bromopropane); Specificgravity (H2O:1): 1.35 (1-bromopropane); Flash point=-10℃ (cc) (1-bromopropane); Autoignitiontemperature=490℃ (1-bromopropane). Explosive Limitsin air: LEL=4.6%; UEL=unknown. HazardIdentification (based on NFPA-704 M Rating System): (asn-propyl bromide): Health 2, Flammability 3, Reactivity0; (2-bromopropane) Health 2, Flammability 3, Reactivity3. Soluble in water; solubility=0.25% at 20℃ (1-bromopropane).

1-Bromopropane(1-BP), also known as n-propyl bromide, is a colourless to pale yellow liquid with a strong, characteristic sweet odour. It is soluble in some organic solvents and slightly soluble in water. 1-BP is a highly flammable liquid with flash point of 220℃. Its vapor is also flammable.

1-Bromopropane is a solvent that is used in degreasing, dry cleaning, spray adhesives,aerosol solvents and resins and is primarily used as a chemical intermediate in the production of pesticides, quaternary ammonium compounds, flavours and fragrances, and pharmaceuticals in closed processes (NTP, 2013). In the mid-to-late 1990s, 1-bromopropane was introduced as a non-toxic, fast-drying solvent that does not leave surface residue for cleaning metals, plastics, and optical, electrical and electronic components (NTP, 2011; NIOSH, 2013). It was marketed as a substitute solvent for ozone-depleting and other solvents such as trichloroethylene, tetrachloroethylene (perchloroethylene) and methylene chloride. 1-Bromopropane is used for vapour degreasing and immersion cleaning, liquid and spray adhesive applications, fabric dry cleaning, and aerosol spray products (Blando et al., 2010; NTP, 2013).

1-Bromopropane is used as a component of various models of binary mixtures, prepared to study their properties such as viscosity and refractive index.
It can be used as an alkylating reagent:
For the functionalization of seleno-substituted imidazo[1,2-α]pyridine derivatives.
For the synthesis of 1,4-dihydroxy-2-propoxy anthraquinone derivatives.
It can also be used as a reactant:
For the synthesis of Berberine-benzimidazole derivatives.
For the synthesis of alkyl aryl ketones via carbonylative Barbier-Negishi coupling with aryl iodides.

ChEBI: A bromoalkane that is propane carrying a bromo substituent at position 1.

1-Bromopropane can be synthesized by reacting n-propyl alcohol (n-propanol) with excess hydrobromic acid. Water formed as a by-product is quickly removed from the resulting crude product before purification to give the final product. A modification of this reaction procedure involves using bromine with a reducing agent such as sulfur, sulfur dioxide, phosphorus or sodium borohydride. The overall reaction with hydrobromic acid is depicted below.
n-C3H7OH + HBr => n-C3H7Br + H2O
The prefix n (or normal) refers to a “straight chain” hydrocarbon component as opposed to a branched hydrocarbon component, such as the isopropyl group in isopropyl alcohol (i-propyl alcohol or i-propanol) where the hydroxyl (−OH) group is attached to the middle carbon.

Highlyflammable

Tumorigen;Reproductive Effector. Used for making other chemicals.

If this chemical gets into the eyes, remove anycontact lenses at once and irrigate immediately for at least15 min, occasionally lifting upper and lower lids. Seek medical attention immediately. If this chemical contacts theskin, remove contaminated clothing and wash immediatelywith soap and water. Seek medical attention immediately. Ifthis chemical has been inhaled, remove from exposure,begin rescue breathing (using universal precautions, including resuscitation mask) if breathing has stopped and CPR ifheart action has stopped. Transfer promptly to a medicalfacility. When this chemical has been swallowed, get medical attention. Give large quantities of water and inducevomiting. Do not make an unconscious person vomit.

Color Code—Red: Flammability Hazard: Store ina flammable liquid storage area or approved cabinet awayfrom ignition sources and corrosive and reactive materials.Protect against physical damage. Outside or detached storage is preferred. Prior to working with Bromopropane youshould be trained on its proper handling and storage. Storein tightly closed containers in a cool, well-ventilated areaaway from incompatible materials listed above. Metal containers involving the transfer of this chemical should begrounded and bonded. Drums must be equipped with selfclosing valves, pressure vacuum bungs, and flame arresters.Use only nonsparking tools and equipment, especially whenopening and closing containers of this chemical. Sources ofignition, such as smoking and open flames, are prohibitedwhere this chemical is used, handled, or stored in a mannerthat could create a potential fire or explosion hazard.

2-Bromopropane requires a “FLAMMABLELIQUID” label. It falls in Hazard Class 3, PackingGroup II.

Likely contaminants include n-propyl alcohol and isopropyl bromide. The simplest purification procedure uses drying with MgSO4 or CaCl2 (with or without a preliminary wash of the bromide with aqueous NaHCO3, then water), followed by fractional distillation away from bright light. Chien and Willard [J Am Chem Soc 79 4872 1957] bubbled a stream of oxygen containing 5% ozone through n-propyl bromide for 1hour, then shook it with 3% hydrogen peroxide solution, neutralised it with aqueous Na2CO3, washed it with distilled water and dried it. This was followed by vigorous stirring with 95% H2SO4 until fresh acid did not discolour within 12hours. The propyl bromide was separated, neutralised, washed, dried with MgSO4 and fractionally distilled. The centre cut was stored in the dark. Instead of ozone, Schuler and McCauley [J Am Chem Soc 79 821 1957] added bromine and stored it for 4 weeks, the bromine then being extracted with aqueous NaHSO3 before the sulfuric acid treatment was applied and finally distilled. Further purification is by preparative gas chromatography on a column packed with 30% SE-30 (General Electric ethylsilicone rubber) on 42/60 Chromosorb P at 150o and 40psi, using helium. [Chu J Phys Chem 41 226 1964, Beilstein 1 IV 205.]

Strong oxidants; strong bases