109-65-9

A clear colorless liquid. Flash point 65°F. Denser than water and insoluble in water. Vapors heavier than air.

1-BROMOBUTANE(109-65-9) is incompatible with strong bases and oxidizers [USCG, 1999].

Highly flammable. Insoluble in water.

Flammable, dangerous fire risk.

Irritating to the eyes, nose, throat, and upper respiratory tract. Symptoms of exposure include burning sensation, coughing, wheezing, laryngitis, shortness of breath, headache, nausea, and vomiting. Irritating to the skin.

Butyl bromide is a highly flammable, colorless liquid with a pleasant odor. Molecular weight 5 137.04. Specific gravity (H2O:1) 5 1.28 @ 20C; boiling point 5 101.3C; freezing/melting point 5 2112.4; vapor pressure 5 42 mmHg @ 25C; vapor density (air 5 1) 5 4.68; flash point 5 17.2C (n-); 21C (sec-isomer). Autoignition temperature 5 269C. Explosive limits: LEL: 2.5% @ 100C; UEL: 6.6% @ 100C. Hazard identification (based on NFPA-704 M Rating System): Health 1; flammability 3; reactivity 0 ?. Insoluble in water

If this chemical gets into the eyes, remove any contact lenses at once and irrigate immediately for at least 15 minutes, occasionally lifting upper and lower lids. Seek medical attention immediately. If this chemical contacts the skin, remove contaminated clothing and wash immediately with soap and water. Seek medical attention immediately. If this chemical has been inhaled, remove from exposure, begin rescue breathing (using universal precautions, including resuscitation mask) if breathing has stopped and CPR if heart action has stopped. Transfer promptly to a medical facility. When this chemical has been swallowed, get medical attention. Give large quantities of water and induce vomiting. Do not make an unconscious person vomit

UN1126 & UN23391- & 2-Bromobutane, Hazard Class: 3; Labels: 3—Flammable liquid.

Vapor may form explosive mixture with air. Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides. May accumulate static electrical charges and cause ignition of its vapors.

Butyl bromide is a highly flammable, colorlessliquid with a pleasant odor. Molecular weight = 137.04.Boiling point =101.6℃; Specific gravity (H2O:1) = 1.276at 20℃; Freezing/Melting point = 2112.4; Vapor density(air 5 1) = 4.68; Flash point =18℃ (21℃ for sec-isomer).Autoigniton temperature = 265℃. Explosive limits:LEL =2.6% at 100℃; UEL =6.6% at 100℃. HazardIdentification (based on NFPA-704 M Rating System):Health 2, Flammability 3, Reactivity 0. Insoluble in water.

clear colorless to slightly yellow liquid

Dissolve or mix the material with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber. All federal, state, and local environmental regulations must be observed

1-Bromobutane is used in the synthesis of procaine and tetracaine.

1-Bromobutane may be used as a derivatization reagent for multiple functional groups (amino, carboxyl, and phenolic hydroxyl groups) of amino acids to improve hydrophobicities and basicities of the amino acids. It may also be used as an internal standard for the quantification of 1- and 2-bromopropane in human urine by headspace gas chromatography.

Journal of the American Chemical Society, 86, p. 964, 1964 DOI: 10.1021/ja01059a073
Organic Syntheses, Coll. Vol. 1, p. 25, 1941
Synthesis, p. 326, 1982

1-bromobutane is a primary alkyl halide (primary alkyl) and therefore it is produced from bimolecular nucleophilic substitution reactions (Sn2).
The preparation method of 1-bromobutane is as follows: stirring n-butanol, sodium bromide, water and sulfuric acid evenly, heating under reflux for 3 hours, steaming out the crude bromobutane, washing with water, treating with cold concentrated sulfuric acid, and distilling to obtain the finished product.
Reaction equation: CH3CH2CH2CH2OH+NaBr+H2SO4→CH3CH2CH2CH2Br+Na2SO4+H2O
This halide is easily prepared by reacting butan-1-ol (primary alcohol) with sodium bromide solution and excess of concentrated sulfuric acid. The reaction between sodium bromide and sulphuric acid origins hydrobromic acid.

Color Code—Red: Flammability Hazard: Store ina flammable liquid storage area or approved cabinet awayfrom ignition sources and corrosive and reactive materials.Prior to working with Butyl bromide you should be trainedon its proper handling and storage. Store in tightly closedcontainers in a cool, well-ventilated area. Sources of ignition, such as smoking and open flames, are prohibitedwhere Butyl bromide is handled, used, or stored. Metal containers involving the transfer of 5 gallons or more of Butylbromide should be grounded and bonded. Drums must beequipped with self-closing valves, pressure vacuum bungs,and flame arresters. Use only nonsparking tools and equipment, especially when opening and closing containers ofButyl bromide.

Wash the bromide with conc H2SO4, water, 10% Na2CO3 and again with H2O. Dry it over CaCl2, CaSO4 or K2CO3, and distil it. Redistil it after drying with P2O5, or pass it through two columns containing 5:1 silica gel/Celite mixture and store it with freshly activated alumina. [Beilstein 1 IV 258.]