123-62-6

Colorless liquid with a pungent odor. Flash point 165°F. Density 8.4 lb /gal. Corrosive to metals and tissue.

PROPIONIC ANHYDRIDE(123-62-6) reacts exothermically with water. The reactions are sometimes slow, but can become violent when local heating accelerates their rate. Acids accelerate the reaction with water. Incompatible with acids, strong oxidizing agents, alcohols, amines, and bases.

Decomposes exothermically in water to form a corrosive solution of propionic acid [Merck, 11th ed. 1989].

Strong irritant to tissue.

Inhalation causes irritation of eyes and respiratory tract. Contact with liquid causes burns of eyes and skin. Ingestion causes burns of mouth and stomach.

Used in the manufacture of perfumes, flavorings, alkyd resins; dyestuffs, pharmaceuticals; as an esterifying agent for fats, oils, and cellulose; dehydrating medium for nitrations and sulfonations.

Combustible material: may burn but does not ignite readily. Substance will react with water (some violently) releasing flammable, toxic or corrosive gases and runoff. When heated, vapors may form explosive mixtures with air: indoors, outdoors and sewers explosion hazards. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapors may travel to source of ignition and flash back. Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated or if contaminated with water.

If this chemical gets into the eyes, remove any contact lenses at once and irrigate immediately for at least 15 minutes, occasionally lifting upper and lower lids. Seek medical attention immediately. If this chemical contacts the skin, remove contaminated clothing and wash immediately with soap and water. Seek medical attention immediately. If this chemical has been inhaled, remove from exposure, begin rescue breathing (using universal precautions, includ- ing resuscitation mask) if breathing has stopped and CPR if heart action has stopped. Transfer promptly to a medical facility. When this chemical has been swallowed, get medi- cal attention. If victim is conscious, administer water, or milk. Do not induce vomiting. Medical observation is recommended for 24?48 hours after breathing overexpo- sure, as pulmonary edema may be delayed. As first aid for pulmonary edema, a doctor or authorized paramedic may consider administering a drug or other inhalation therapy.

UN2496 Propionic anhydride, Hazard class: 8; Labels: 8-Corrosive material.

Vapors may form explosive mixture with air. Incompatible with oxidizers (chlorates, nitrates, perox- ides, permanganates, perchlorates, chlorine, bromine, fluo- rine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides, reducing agents; alcohols and metals. Contact with water forms heat 1 flammable propionic acid. Compounds of the carboxyl group react with all bases, both inorganic and organic (i.e., amines) releasing substantial heat, water and a salt that may be harmful. Incompatible with arsenic compounds (releases hydrogen cyanide gas), diazo compounds, dithiocarbamates, isocyanates, mercap- tans, nitrides, and sulfides (releasing heat, toxic and possibly flammable gases), thiosulfates and dithionites (releasing hydrogen sulfate and oxides of sulfur).

Propanoic anhydride is an organic compound with the formula (CH₃CH₂CO)₂O. This simple acid anhydride is a colourless liquid. It is a widely used reagent in organic synthesis.

colourless liquid with an unpleasant odour

Propionic anhydride is a colorless liquid. Strong, pungent, unpleasant odor.

Use a licensed professional waste disposal service to dispose of this material. Dissolve or mix the material with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber. All federal, state, and local environmental regulations must be observed.

Esterifying agent for certain perfume oils, fats, oils, and especially cellulose. In the production of alkyd resins, dyestuffs and drugs. Has been used as a dehydrating agent in some sulfonations and nitrations.

Usually used in the preparation of α- and β-1-propionyl derivatives of glucopyranose tetra-acetate.

Propionic anhydride was previously used in the preparation of α and β-1-propionyl derivatives of glucopyranose tetra-acetate.

Nonflammable

Propanoic anhydride is strong smelling and corrosive, and will cause burns on contact with skin. Vapour can burn eyes and lungs.

Propanoic anhydride has been prepared by dehydration of propanoic acid using ketene :
2 CH₃CH₂CO₂H + CH₂= C= O → (CH₃CH₂CO)₂O + CH₃CO₂H.

Shake the anhydride with P2O5 for several minutes, then distil. [Beilstein 2 IV 722.]