ChemicalBook CAS DataBase List 336-59-4

336-59-4

Name	Heptafluorobutyric anhydride
CAS	336-59-4
EINECS(EC#)	206-410-8
Molecular Formula	C8F14O3
MDL Number	MFCD00000432
Molecular Weight	410.06
MOL File	336-59-4.mol

Synonyms

AKOS B020344 BIS(HEPTAFLUORO-N-BUTYRIC) ANHYDRIDE HEPTAFLUOROBUTYRIC ACID ANHYDRIDE HEPTAFLUOROBUTYRIC ANHYDRIDE HEPTAFLUORO-N-BUTYRIC ANHYDRIDE HFAA HFBA PERFLUOROBUTYRIC ANHYDRIDE PERFLUORO-N-BUTYRIC ANHYDRIDE 1,1,2,2,3,3,3-Heptafluorobutanoic anhydride Butanoic acid, heptafluoro-, anhydride Butanoicacid,heptafluoro-,anhydride Heptafluorobutanoic anhydride heptafluoro-butanoicacianhydride HEPTAFLUOROBUTYRIC ANHYDRIDE SET WITH 10 X 1 ML HEPTAFLUOROBUTYRIC ANHYDRIDE, DERIVATIZA TION GRADE Heptafluorobutyric anhydride, 98+% Heptafluorobutyric anhydride 98% Heptafluorobutyric anhydride 99+% heptafluoro-butanoic acid anhydride

Chemical Properties

Appearance	clear colorless liquid
Melting point	−43 °C(lit.)
Boiling point	108-110 °C(lit.)
density	1.674 g/mL at 20 °C(lit.)
refractive index	n20/D 1.287(lit.)
Fp	None
storage temp.	Room temp
solubility	Miscible with halogenated solvents. Immiscible with polar solvents.
form	Liquid
color	Colorless to Almost colorless
Specific Gravity	1.653
Water Solubility	REACTS
Sensitive	Hygroscopic
Detection Methods	GC,NMR,MS
BRN	856036
Stability:	Moisture Sensitive
InChI	1S/C8F14O3/c9-3(10,5(13,14)7(17,18)19)1(23)25-2(24)4(11,12)6(15,16)8(20,21)22
InChIKey	UFFSXJKVKBQEHC-UHFFFAOYSA-N
SMILES	FC(F)(F)C(F)(F)C(F)(F)C(=O)OC(=O)C(F)(F)C(F)(F)C(F)(F)F
CAS DataBase Reference	336-59-4(CAS DataBase Reference)
NIST Chemistry Reference	Heptafluorobutyric anhydride(336-59-4)
Storage Precautions	Moisture sensitive
EPA Substance Registry System	336-59-4(EPA Substance)

Safety Data

Symbol(GHS)	GHS05
Signal word	Danger
Hazard statements	H314
Precautionary statements	P280-P303+P361+P353-P304+P340+P310-P305+P351+P338-P363-P405
Hazard Codes	C
Risk Statements	R34:Causes burns. less more
Safety Statements	S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice . S36/37/39:Wear suitable protective clothing, gloves and eye/face protection . S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) . less more
RIDADR	UN 3265 8/PG 2
WGK Germany	3
F	10-21
Hazard Note	Corrosive/Hygroscopic
TSCA	T
HazardClass	8
PackingGroup	III
HS Code	29159080
Storage Class	8A - Combustible corrosive hazardous materials
Hazard Classifications	Skin Corr. 1B

Raw materials And Preparation Products

Hazard Information

Chemical Properties

clear colorless liquid

Uses

As a GC derivatizing agent, Heptafluorobutyric anhydride is used to prepare volatile derivatives of amino acids and other biologically active compounds.

Uses

Heptafluorobutyric anhydride (HFAA) is frequently used as an acylating agent for the derivatization of primary and secondary amines (Walle and Ehrsson, 1971). Commercially available Heptafluorobutyric anhydride may afford low yields of the derivative due to the presence of Heptafluorobutyric acid (Moodie et al., 1985). This contaminant may be removed by ditillation over phosphorus pentoxide (Walle and Ehrsson, 1970).
HFAA is used to increase volatility of an analyte, and to introduce fluorine atoms for better detection limits in gas chromatography applications.
suzuki reaction

Definition

ChEBI: An acyclic carboxylic anhydride that is perfluorinated butyric anhydride. It is used as a derivatising reagent for gas chromatographic analyses.

General Description

Heptafluorobutyric anhydride is a perfluoroacylated acylation reagent, that forms stable, volatile derivatives with alcohols, amines, and phenols. It is majorly used to prepare electron-capturing derivatives for GC/electron capture detection. It is generally used with an acid scavenger, to help drive the reaction to completion and to prevent column damage from acidic by-products of the derivatization reaction. It is also used for the frequent testing of drugs of abuse such as, amphetamines and phencyclidine by GC-MS technique.

reaction suitability

reagent type: derivatization reagent
reaction type: Acylations

Material Safety Data Sheet(MSDS)

Spectrum Detail

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