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• Synthesis

  Currently, the synthesis of trimethylacetic anhydride from terpentine is mainly achieved through dehydrating agents or by the action of acetic anhydride. This method requires the use of dehydrating agents that cause severe environmental pollution, and the production process is long, involves many steps, requires high investment in equipment and infrastructure, and demands high corrosion resistance from the equipment. If acetic anhydride is used to induce an exchange dehydration reaction, the reaction time is also relatively long. Therefore, a systematic study of the preparation process of trimethylacetic anhydride is of great significance. The synthesis reaction formula of trimethylacetic anhydride is shown in the figure below:

  

  Figure 1 Synthesis reaction formula of trimethylacetic anhydride

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• Mechanism of Hydrolysis

  The acid hydrolysis of trimethylacetic anhydride follows an A-2 mechanism in both water and aqueous dioxane and is slower than that of acetic anhydride. acetic anhydride also follows an A-2 mechanism.
  
  These observations suggest that the acid hydrolysis of Perchloric, sulfuric, and hydrochloric acid catalyze hydrolysis to different extents, and plots of the logarithms of the rate constants against log [H+] or Ho are curved. These reactions are likely to involve a bimolecular attack by water molecules on the anhydride or its conjugate acid, as the methyl group is expected to hinder the incoming nucleophile through steric hindrance and, possibly, through inductive effects[1].;

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